Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Laura A. Hundahl, Jacob Tfelt-Hansen, Thomas Jespersen*

*Corresponding author for this work
6 Citations (Scopus)

Abstract

A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume22
Issue number6
Pages (from-to)514-528
Number of pages15
ISSN1074-2484
DOIs
Publication statusPublished - Nov 2017

Keywords

  • myocardial infarction
  • rat models
  • sudden cardiac death
  • ventricular arrhythmias

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