Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Laura A. Hundahl; Jacob Tfelt-Hansen; Thomas Jespersen

doi:10.1177/1074248417702894

Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Laura A. Hundahl, Jacob Tfelt-Hansen, Thomas Jespersen^*

^*Corresponding author af dette arbejde

6 Citationer (Scopus)

Abstract

A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.

Originalsprog	Engelsk
Tidsskrift	Journal of Cardiovascular Pharmacology and Therapeutics
Vol/bind	22
Udgave nummer	6
Sider (fra-til)	514-528
Antal sider	15
ISSN	1074-2484
DOI	https://doi.org/10.1177/1074248417702894
Status	Udgivet - nov. 2017

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10.1177/1074248417702894

Citationsformater

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title = "Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction",

abstract = "A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.",

keywords = "myocardial infarction, rat models, sudden cardiac death, ventricular arrhythmias",

author = "Hundahl, {Laura A.} and Jacob Tfelt-Hansen and Thomas Jespersen",

year = "2017",

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language = "English",

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TY - JOUR

T1 - Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

AU - Hundahl, Laura A.

AU - Tfelt-Hansen, Jacob

AU - Jespersen, Thomas

PY - 2017/11

Y1 - 2017/11

N2 - A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.

AB - A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.

KW - myocardial infarction

KW - rat models

KW - sudden cardiac death

KW - ventricular arrhythmias

U2 - 10.1177/1074248417702894

DO - 10.1177/1074248417702894

M3 - Journal article

C2 - 28381093

AN - SCOPUS:85032289645

SN - 1074-2484

VL - 22

SP - 514

EP - 528

JO - Journal of Cardiovascular Pharmacology and Therapeutics

JF - Journal of Cardiovascular Pharmacology and Therapeutics

IS - 6

ER -

Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

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