Abstract
A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.
| Original language | English |
|---|---|
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Issue number | 5-6 |
| Pages (from-to) | 318-320 |
| ISSN | 0362-4803 |
| DOIs | |
| Publication status | Published - May 2010 |
| Event | 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds - Chicago, United States Duration: 14 Jun 2009 → 18 Jun 2009 Conference number: 10 |
Conference
| Conference | 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds |
|---|---|
| Number | 10 |
| Country/Territory | United States |
| City | Chicago |
| Period | 14/06/2009 → 18/06/2009 |
Keywords
- Former Faculty of Pharmaceutical Sciences