Radioiododestannyllation of novel GHB neuroreceptor ligands

Martin Holst Friborg Pedersen; Signe Høg; Petrine Wellendorph; Lars Martiny

doi:10.1002/jlcr.1767

Radioiododestannyllation of novel GHB neuroreceptor ligands

Martin Holst Friborg Pedersen, Signe Høg, Petrine Wellendorph, Lars Martiny

1 Citationer (Scopus)

Abstract

A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.^1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.

Originalsprog	Engelsk
Tidsskrift	Journal of Labelled Compounds and Radiopharmaceuticals
Udgave nummer	5-6
Sider (fra-til)	318-320
ISSN	0362-4803
DOI	https://doi.org/10.1002/jlcr.1767
Status	Udgivet - maj 2010
Begivenhed	10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds - Chicago, USA Varighed: 14 jun. 2009 → 18 jun. 2009 Konferencens nummer: 10

Konference

Konference	10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds
Nummer	10
Land/Område	USA
By	Chicago
Periode	14/06/2009 → 18/06/2009

Emneord

Det tidligere Farmaceutiske Fakultet

Adgang til dokumentet

10.1002/jlcr.1767

Citationsformater

@inproceedings{d580ba80eb3d11dfb6d2000ea68e967b,

title = "Radioiododestannyllation of novel GHB neuroreceptor ligands",

abstract = "A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Pedersen, {Martin Holst Friborg} and Signe H{\o}g and Petrine Wellendorph and Lars Martiny",

note = "Keywords: radioiododestannylation; GHB; iodine-125; chloramine-T; 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds ; Conference date: 14-06-2009 Through 18-06-2009",

year = "2010",

month = may,

doi = "10.1002/jlcr.1767",

language = "English",

pages = "318--320",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "JohnWiley & Sons Ltd",

number = "5-6",

}

TY - GEN

T1 - Radioiododestannyllation of novel GHB neuroreceptor ligands

AU - Pedersen, Martin Holst Friborg

AU - Høg, Signe

AU - Wellendorph, Petrine

AU - Martiny, Lars

N1 - Conference code: 10

PY - 2010/5

Y1 - 2010/5

N2 - A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.

AB - A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/jlcr.1767

DO - 10.1002/jlcr.1767

M3 - Conference article

SN - 0362-4803

SP - 318

EP - 320

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 5-6

T2 - 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds

Y2 - 14 June 2009 through 18 June 2009

ER -

Radioiododestannyllation of novel GHB neuroreceptor ligands

Abstract

Konference

Emneord

Adgang til dokumentet

Fingeraftryk

Citationsformater