Radioiododestannyllation of novel GHB neuroreceptor ligands

TY - GEN

T1 - Radioiododestannyllation of novel GHB neuroreceptor ligands

AU - Pedersen, Martin Holst Friborg

AU - Høg, Signe

AU - Wellendorph, Petrine

AU - Martiny, Lars

N1 - Conference code: 10

PY - 2010/5

Y1 - 2010/5

N2 - A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.

AB - A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/jlcr.1767

DO - 10.1002/jlcr.1767

M3 - Conference article

SN - 0362-4803

SP - 318

EP - 320

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 5-6

T2 - 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds

Y2 - 14 June 2009 through 18 June 2009

ER -