Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

TY - JOUR

T1 - Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

AU - Chiu, Tim T

AU - Jensen, Thomas Elbenhardt

AU - Sylow, Lykke

AU - Richter, Erik

AU - Klip, Amira

N1 - CURIS 2011 5200 065

PY - 2011/10

Y1 - 2011/10

N2 - Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

AB - Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

U2 - 10.1016/j.cellsig.2011.05.022

DO - 10.1016/j.cellsig.2011.05.022

M3 - Review

C2 - 21683139

SN - 0898-6568

VL - 23

SP - 1546

EP - 1554

JO - Cellular Signalling

JF - Cellular Signalling

IS - 10

ER -