Quantification of retinal layer thickness changes in acute macular neuroretinopathy

Marion R. Munk; Marco Beck; Simone Kolb; Michael Larsen; Steffen Hamann; Christophe Valmaggia; Martin S. Zinkernagel

doi:10.1136/bjophthalmol-2016-308367

Quantification of retinal layer thickness changes in acute macular neuroretinopathy

Marion R. Munk, Marco Beck, Simone Kolb, Michael Larsen, Steffen Hamann, Christophe Valmaggia, Martin S. Zinkernagel^*

^*Corresponding author for this work

Department of Clinical Medicine

6 Citations (Scopus)

32 Downloads (Pure)

Abstract

Purpose To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN). Methods AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up. Results Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 μm vs 73±17 μm, p=0.002). The other layers, including inner nuclear layer (37±8 μm vs 38±6 μm, p=0.9) and outer plexiform layer (OPL) (45±19 μm vs 33±16 μm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 μm vs fellow eye: 39±16 μm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 μm vs fellow eye: 69±16 μm, p=0.002). Conclusions AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.

Original language	English
Journal	British Journal of Ophthalmology
Volume	101
Issue number	2
Pages (from-to)	160-165
Number of pages	6
ISSN	0007-1161
DOIs	https://doi.org/10.1136/bjophthalmol-2016-308367
Publication status	Published - Feb 2017

Keywords

Imaging
Macula

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title = "Quantification of retinal layer thickness changes in acute macular neuroretinopathy",

abstract = "Purpose To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN). Methods AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up. Results Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 μm vs 73±17 μm, p=0.002). The other layers, including inner nuclear layer (37±8 μm vs 38±6 μm, p=0.9) and outer plexiform layer (OPL) (45±19 μm vs 33±16 μm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 μm vs fellow eye: 39±16 μm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 μm vs fellow eye: 69±16 μm, p=0.002). Conclusions AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.",

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author = "Munk, {Marion R.} and Marco Beck and Simone Kolb and Michael Larsen and Steffen Hamann and Christophe Valmaggia and Zinkernagel, {Martin S.}",

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AU - Munk, Marion R.

AU - Beck, Marco

AU - Kolb, Simone

AU - Larsen, Michael

AU - Hamann, Steffen

AU - Valmaggia, Christophe

AU - Zinkernagel, Martin S.

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N2 - Purpose To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN). Methods AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up. Results Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 μm vs 73±17 μm, p=0.002). The other layers, including inner nuclear layer (37±8 μm vs 38±6 μm, p=0.9) and outer plexiform layer (OPL) (45±19 μm vs 33±16 μm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 μm vs fellow eye: 39±16 μm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 μm vs fellow eye: 69±16 μm, p=0.002). Conclusions AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.

AB - Purpose To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN). Methods AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up. Results Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 μm vs 73±17 μm, p=0.002). The other layers, including inner nuclear layer (37±8 μm vs 38±6 μm, p=0.9) and outer plexiform layer (OPL) (45±19 μm vs 33±16 μm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 μm vs fellow eye: 39±16 μm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 μm vs fellow eye: 69±16 μm, p=0.002). Conclusions AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.

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Quantification of retinal layer thickness changes in acute macular neuroretinopathy

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