Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

TY - JOUR

T1 - Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

AU - Yang, Liang

AU - Nilsson, Martin

AU - Gjermansen, Morten

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

PY - 2009

Y1 - 2009

N2 - Summary Using flow chamber-grown Pseudomonas aeruginosa biofilms as model system, we show in the present study that formation of heterogeneous biofilms may occur through mechanisms that involve complex subpopulation interactions. One example of this phenomenon is expression of the iron-siderophore pyoverdine in one subpopulation being necessary for development of another subpopulation that does not itself express the pyoverdine synthesis genes. Another example is quorum sensing-controlled DNA release in one subpopulation being necessary for development of another subpopulation that does not itself express the quorum-sensing genes.

AB - Summary Using flow chamber-grown Pseudomonas aeruginosa biofilms as model system, we show in the present study that formation of heterogeneous biofilms may occur through mechanisms that involve complex subpopulation interactions. One example of this phenomenon is expression of the iron-siderophore pyoverdine in one subpopulation being necessary for development of another subpopulation that does not itself express the pyoverdine synthesis genes. Another example is quorum sensing-controlled DNA release in one subpopulation being necessary for development of another subpopulation that does not itself express the quorum-sensing genes.

U2 - 10.1111/j.1365-2958.2009.06934.x

DO - 10.1111/j.1365-2958.2009.06934.x

M3 - Journal article

C2 - 19889094

SN - 0950-382X

VL - 74

SP - 1380

EP - 1392

JO - Molecular Microbiology

JF - Molecular Microbiology

IS - 6

ER -