Pulmonary drug delivery to older people

Martin Wallin; Tatsuaki Tagami; Lan Chen; Mingshi Yang; Hak Kim Chan

doi:10.1016/j.addr.2017.11.010

Pulmonary drug delivery to older people

Martin Wallin, Tatsuaki Tagami, Lan Chen, Mingshi Yang, Hak Kim Chan^*

^*Corresponding author for this work

8 Citations (Scopus)

Abstract

Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions. Adjusting and optimizing the inhaler device to the patient preferences, improvement of the drug formulation and inhalers, and using different adherence strategies might improve the treatment outcomes in elderly patients.

Original language	English
Journal	Advanced Drug Delivery Reviews
Volume	135
Pages (from-to)	50-61
Number of pages	12
ISSN	0169-409X
DOIs	https://doi.org/10.1016/j.addr.2017.11.010
Publication status	Published - 1 Oct 2018

Keywords

Elderly patients
Inhalation drug delivery
Inhaler devices
Medication adherence strategies
Pharmacokinetics and pharmacodynamics

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10.1016/j.addr.2017.11.010

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title = "Pulmonary drug delivery to older people",

abstract = "Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions. Adjusting and optimizing the inhaler device to the patient preferences, improvement of the drug formulation and inhalers, and using different adherence strategies might improve the treatment outcomes in elderly patients.",

keywords = "Elderly patients, Inhalation drug delivery, Inhaler devices, Medication adherence strategies, Pharmacokinetics and pharmacodynamics",

author = "Martin Wallin and Tatsuaki Tagami and Lan Chen and Mingshi Yang and Chan, {Hak Kim}",

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T1 - Pulmonary drug delivery to older people

AU - Wallin, Martin

AU - Tagami, Tatsuaki

AU - Chen, Lan

AU - Yang, Mingshi

AU - Chan, Hak Kim

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions. Adjusting and optimizing the inhaler device to the patient preferences, improvement of the drug formulation and inhalers, and using different adherence strategies might improve the treatment outcomes in elderly patients.

AB - Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions. Adjusting and optimizing the inhaler device to the patient preferences, improvement of the drug formulation and inhalers, and using different adherence strategies might improve the treatment outcomes in elderly patients.

KW - Elderly patients

KW - Inhalation drug delivery

KW - Inhaler devices

KW - Medication adherence strategies

KW - Pharmacokinetics and pharmacodynamics

U2 - 10.1016/j.addr.2017.11.010

DO - 10.1016/j.addr.2017.11.010

M3 - Journal article

C2 - 29197631

AN - SCOPUS:85044711144

SN - 0169-409X

VL - 135

SP - 50

EP - 61

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Pulmonary drug delivery to older people

Abstract

Keywords

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