Abstract
Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.
| Original language | English |
|---|---|
| Journal | Journal of Histochemistry and Cytochemistry |
| Volume | 62 |
| Issue number | 3 |
| Pages (from-to) | 172-84 |
| Number of pages | 13 |
| ISSN | 0022-1554 |
| DOIs | |
| Publication status | Published - Mar 2014 |
Keywords
- Animals
- Cell Movement
- Enzyme Activation
- Focal Adhesions
- Humans
- Protein Kinase C