Protein kinase C, focal adhesions and the regulation of cell migration

TY - JOUR

T1 - Protein kinase C, focal adhesions and the regulation of cell migration

AU - Fogh, Betina S

AU - Multhaupt, Hinke A B

AU - Couchman, John Robert

PY - 2014/3

Y1 - 2014/3

N2 - Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.

AB - Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.

KW - Animals

KW - Cell Movement

KW - Enzyme Activation

KW - Focal Adhesions

KW - Humans

KW - Protein Kinase C

U2 - 10.1369/0022155413517701

DO - 10.1369/0022155413517701

M3 - Review

C2 - 24309511

SN - 0022-1554

VL - 62

SP - 172

EP - 184

JO - Journal of Histochemistry and Cytochemistry

JF - Journal of Histochemistry and Cytochemistry

IS - 3

ER -