Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Lisa Frankel; Nanna R Christoffersen; Anders Jacobsen; Morten Lindow; Anders Krogh; Anders Henrik Lund

doi:10.1074/jbc.M707224200

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Lisa Frankel, Nanna R Christoffersen, Anders Jacobsen, Morten Lindow, Anders Krogh, Anders Henrik Lund

929 Citations (Scopus)

Abstract

MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

Original language	English
Journal	Journal of Biological Chemistry
Volume	283
Issue number	2
Pages (from-to)	1026-33
Number of pages	7
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M707224200
Publication status	Published - 2008

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@article{65b6f4d0526011dd8d9f000ea68e967b,

title = "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.",

abstract = "MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.",

author = "Lisa Frankel and Christoffersen, {Nanna R} and Anders Jacobsen and Morten Lindow and Anders Krogh and Lund, {Anders Henrik}",

note = "Keywords: Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Kinetics; MicroRNAs; RNA, Neoplasm; RNA-Binding Proteins",

year = "2008",

doi = "10.1074/jbc.M707224200",

language = "English",

volume = "283",

pages = "1026--33",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology, Inc.",

number = "2",

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TY - JOUR

T1 - Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

AU - Frankel, Lisa

AU - Christoffersen, Nanna R

AU - Jacobsen, Anders

AU - Lindow, Morten

AU - Krogh, Anders

AU - Lund, Anders Henrik

N1 - Keywords: Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Kinetics; MicroRNAs; RNA, Neoplasm; RNA-Binding Proteins

PY - 2008

Y1 - 2008

N2 - MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

AB - MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

U2 - 10.1074/jbc.M707224200

DO - 10.1074/jbc.M707224200

M3 - Journal article

C2 - 17991735

SN - 0021-9258

VL - 283

SP - 1026

EP - 1033

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 2

ER -

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.

Abstract

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