@article{65b6f4d0526011dd8d9f000ea68e967b,
title = "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.",
abstract = "MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.",
author = "Lisa Frankel and Christoffersen, {Nanna R} and Anders Jacobsen and Morten Lindow and Anders Krogh and Lund, {Anders Henrik}",
note = "Keywords: Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Breast Neoplasms; Cell Division; Cell Line, Tumor; Female; Humans; Kinetics; MicroRNAs; RNA, Neoplasm; RNA-Binding Proteins",
year = "2008",
doi = "10.1074/jbc.M707224200",
language = "English",
volume = "283",
pages = "1026--33",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "2",
}
