Production of β-chemokines in human immunodeficiency virus (HIV) infection: Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression

Henrik Ullum; Alessandro Cozzi Lepri; Jette Victor; Hassan Aladdin; Andrew N. Phillips; Jan Gerstoft; Peter Skinhøj; Bente Klarlund Pedersen

doi:10.1086/514192

Production of β-chemokines in human immunodeficiency virus (HIV) infection: Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression

Henrik Ullum^*, Alessandro Cozzi Lepri, Jette Victor, Hassan Aladdin, Andrew N. Phillips, Jan Gerstoft, Peter Skinhøj, Bente Klarlund Pedersen

^*Corresponding author for this work

Department of Clinical Medicine

99 Citations (Scopus)

Abstract

Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES production were measured by ELISA in whole blood that had been stimulated for 4.5 h with phytohemagglutinin. The blood was from 90 healthy human immunodeficiency virus (HIV)-negative controls and from 245 HIV-infected subjects who were followed for ≤4.5 years. HIV-infected persons without AIDS had increased levels of MIP-1α, MIP-1β, and RANTES (P < .01) compared with levels in controls. Subjects with AIDS, compared with controls, had decreased production levels of MIP-1β (P < .0001) and similar levels of MIP-1α and RANTES. A high level of MIP-1β production was associated with a decreased risk of progressing to AIDS or death, as determined by univariate analysis (P < .01) and adjusted for CD4 cell count and age (P = .07, P = .06, respectively). The findings suggest that the production level of β-chemokine changes during HIV infection and that a high level of β-chemokine production in peripheral blood lymphocytes may be associated with less rapid disease progression in HIV infection.

Original language	English
Journal	Journal of Infectious Diseases
Volume	177
Issue number	2
Pages (from-to)	331-336
Number of pages	6
ISSN	0022-1899
DOIs	https://doi.org/10.1086/514192
Publication status	Published - 1 Jan 1998

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Ullum, H., Lepri, A. C., Victor, J., Aladdin, H., Phillips, A. N., Gerstoft, J., Skinhøj, P., & Pedersen, B. K. (1998). Production of β-chemokines in human immunodeficiency virus (HIV) infection: Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression. Journal of Infectious Diseases, 177(2), 331-336. https://doi.org/10.1086/514192

Production of β-chemokines in human immunodeficiency virus (HIV) infection : Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression. / Ullum, Henrik; Lepri, Alessandro Cozzi; Victor, Jette et al.

In: Journal of Infectious Diseases, Vol. 177, No. 2, 01.01.1998, p. 331-336.

Research output: Contribution to journal › Journal article › Research › peer-review

Ullum, H, Lepri, AC, Victor, J, Aladdin, H, Phillips, AN, Gerstoft, J, Skinhøj, P & Pedersen, BK 1998, 'Production of β-chemokines in human immunodeficiency virus (HIV) infection: Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression', Journal of Infectious Diseases, vol. 177, no. 2, pp. 331-336. https://doi.org/10.1086/514192

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abstract = "Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES production were measured by ELISA in whole blood that had been stimulated for 4.5 h with phytohemagglutinin. The blood was from 90 healthy human immunodeficiency virus (HIV)-negative controls and from 245 HIV-infected subjects who were followed for ≤4.5 years. HIV-infected persons without AIDS had increased levels of MIP-1α, MIP-1β, and RANTES (P < .01) compared with levels in controls. Subjects with AIDS, compared with controls, had decreased production levels of MIP-1β (P < .0001) and similar levels of MIP-1α and RANTES. A high level of MIP-1β production was associated with a decreased risk of progressing to AIDS or death, as determined by univariate analysis (P < .01) and adjusted for CD4 cell count and age (P = .07, P = .06, respectively). The findings suggest that the production level of β-chemokine changes during HIV infection and that a high level of β-chemokine production in peripheral blood lymphocytes may be associated with less rapid disease progression in HIV infection.",

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Production of β-chemokines in human immunodeficiency virus (HIV) infection: Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression

Abstract

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