TY - JOUR
T1 - Production of β-chemokines in human immunodeficiency virus (HIV) infection
T2 - Evidence that high levels of macrophage inflammatory protein-1β are associated with a decreased risk of HIV disease progression
AU - Ullum, Henrik
AU - Lepri, Alessandro Cozzi
AU - Victor, Jette
AU - Aladdin, Hassan
AU - Phillips, Andrew N.
AU - Gerstoft, Jan
AU - Skinhøj, Peter
AU - Pedersen, Bente Klarlund
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES production were measured by ELISA in whole blood that had been stimulated for 4.5 h with phytohemagglutinin. The blood was from 90 healthy human immunodeficiency virus (HIV)-negative controls and from 245 HIV-infected subjects who were followed for ≤4.5 years. HIV-infected persons without AIDS had increased levels of MIP-1α, MIP-1β, and RANTES (P < .01) compared with levels in controls. Subjects with AIDS, compared with controls, had decreased production levels of MIP-1β (P < .0001) and similar levels of MIP-1α and RANTES. A high level of MIP-1β production was associated with a decreased risk of progressing to AIDS or death, as determined by univariate analysis (P < .01) and adjusted for CD4 cell count and age (P = .07, P = .06, respectively). The findings suggest that the production level of β-chemokine changes during HIV infection and that a high level of β-chemokine production in peripheral blood lymphocytes may be associated with less rapid disease progression in HIV infection.
AB - Macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES production were measured by ELISA in whole blood that had been stimulated for 4.5 h with phytohemagglutinin. The blood was from 90 healthy human immunodeficiency virus (HIV)-negative controls and from 245 HIV-infected subjects who were followed for ≤4.5 years. HIV-infected persons without AIDS had increased levels of MIP-1α, MIP-1β, and RANTES (P < .01) compared with levels in controls. Subjects with AIDS, compared with controls, had decreased production levels of MIP-1β (P < .0001) and similar levels of MIP-1α and RANTES. A high level of MIP-1β production was associated with a decreased risk of progressing to AIDS or death, as determined by univariate analysis (P < .01) and adjusted for CD4 cell count and age (P = .07, P = .06, respectively). The findings suggest that the production level of β-chemokine changes during HIV infection and that a high level of β-chemokine production in peripheral blood lymphocytes may be associated with less rapid disease progression in HIV infection.
UR - http://www.scopus.com/inward/record.url?scp=0031908542&partnerID=8YFLogxK
U2 - 10.1086/514192
DO - 10.1086/514192
M3 - Journal article
C2 - 9466518
AN - SCOPUS:0031908542
SN - 0022-1899
VL - 177
SP - 331
EP - 336
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -
