Probing spinal circuits controlling walking in mammals

Ole Kiehn; Kimberly J. Dougherty; Martin Hägglund; Lotta Borgius; Adolfo Talpalar; Carlos Ernesto Restrepo

doi:10.1016/j.bbrc.2010.02.107

Probing spinal circuits controlling walking in mammals

Ole Kiehn^*, Kimberly J. Dougherty, Martin Hägglund, Lotta Borgius, Adolfo Talpalar, Carlos Ernesto Restrepo

^*Corresponding author for this work

Department of Neuroscience

40 Citations (Scopus)

Abstract

Locomotion in mammals is a complex motor act that involves the activation of a large number of muscles in a well-coordinated pattern. Understanding the network organization of the intrinsic spinal networks that control the locomotion, the central pattern generators, has been a challenge to neuroscientists. However, experiments using the isolated rodent spinal cord and combining electrophysiology and molecular genetics to dissect the locomotor network have started to shed new light on the network structure. In the present review, we will discuss findings that have revealed the role of designated populations of neurons for the key network functions including coordinating muscle activity and generating rhythmic activity. These findings are summarized in proposed organizational principles for the mammalian segmental CPG.

Original language	English
Journal	Biochemical and Biophysical Research Communications
Volume	396
Issue number	1
Pages (from-to)	11-18
Number of pages	8
ISSN	0006-291X
DOIs	https://doi.org/10.1016/j.bbrc.2010.02.107
Publication status	Published - 21 May 2010

Keywords

Central pattern generator
Chx10
En1
GATA 3
Hb9
Interneuron
Optogenetic
Sim1
Transgenic mice

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10.1016/j.bbrc.2010.02.107

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AU - Kiehn, Ole

AU - Dougherty, Kimberly J.

AU - Hägglund, Martin

AU - Borgius, Lotta

AU - Talpalar, Adolfo

AU - Restrepo, Carlos Ernesto

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Probing spinal circuits controlling walking in mammals

Abstract

Keywords

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