Probing spinal circuits controlling walking in mammals

Ole Kiehn; Kimberly J. Dougherty; Martin Hägglund; Lotta Borgius; Adolfo Talpalar; Carlos Ernesto Restrepo

doi:10.1016/j.bbrc.2010.02.107

Probing spinal circuits controlling walking in mammals

Ole Kiehn^*, Kimberly J. Dougherty, Martin Hägglund, Lotta Borgius, Adolfo Talpalar, Carlos Ernesto Restrepo

^*Corresponding author af dette arbejde

Institut for Neurovidenskab

40 Citationer (Scopus)

Abstract

Locomotion in mammals is a complex motor act that involves the activation of a large number of muscles in a well-coordinated pattern. Understanding the network organization of the intrinsic spinal networks that control the locomotion, the central pattern generators, has been a challenge to neuroscientists. However, experiments using the isolated rodent spinal cord and combining electrophysiology and molecular genetics to dissect the locomotor network have started to shed new light on the network structure. In the present review, we will discuss findings that have revealed the role of designated populations of neurons for the key network functions including coordinating muscle activity and generating rhythmic activity. These findings are summarized in proposed organizational principles for the mammalian segmental CPG.

Originalsprog	Engelsk
Tidsskrift	Biochemical and Biophysical Research Communications
Vol/bind	396
Udgave nummer	1
Sider (fra-til)	11-18
Antal sider	8
ISSN	0006-291X
DOI	https://doi.org/10.1016/j.bbrc.2010.02.107
Status	Udgivet - 21 maj 2010

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AU - Restrepo, Carlos Ernesto

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Probing spinal circuits controlling walking in mammals

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