PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Elke Dorenbos; Mathijs Drummen; Jesse Rijks; Tanja Adam; Pauline Stouthart; J Alfredo Martínez; Santiago Navas-Carretero; Gareth Stratton; Nils Swindell; Mikael Fogelholm; Anne Raben; Margriet Westerterp-Plantenga; Anita Vreugdenhil

doi:10.1111/dom.13216

PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Elke Dorenbos, Mathijs Drummen, Jesse Rijks, Tanja Adam, Pauline Stouthart, J Alfredo Martínez, Santiago Navas-Carretero, Gareth Stratton, Nils Swindell, Mikael Fogelholm, Anne Raben, Margriet Westerterp-Plantenga, Anita Vreugdenhil

Obesity Research

3 Citations (Scopus)

Abstract

Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.

Original language	English
Journal	Diabetes, Obesity and Metabolism
Volume	20
Issue number	5
Pages (from-to)	1096-1101
Number of pages	6
ISSN	1462-8902
DOIs	https://doi.org/10.1111/dom.13216
Publication status	Published - May 2018

Keywords

Dietary intervention
Insulin resistance
Radomized trial
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/dom.13216

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Dorenbos, E., Drummen, M., Rijks, J., Adam, T., Stouthart, P., Martínez, J. A., Navas-Carretero, S., Stratton, G., Swindell, N., Fogelholm, M., Raben, A., Westerterp-Plantenga, M., & Vreugdenhil, A. (2018). PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results. Diabetes, Obesity and Metabolism, 20(5), 1096-1101. https://doi.org/10.1111/dom.13216

PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years : Design, methods and baseline results. / Dorenbos, Elke; Drummen, Mathijs; Rijks, Jesse et al.

In: Diabetes, Obesity and Metabolism, Vol. 20, No. 5, 05.2018, p. 1096-1101.

Research output: Contribution to journal › Journal article › Research › peer-review

Dorenbos, E, Drummen, M, Rijks, J, Adam, T, Stouthart, P, Martínez, JA, Navas-Carretero, S, Stratton, G, Swindell, N, Fogelholm, M, Raben, A, Westerterp-Plantenga, M & Vreugdenhil, A 2018, 'PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results', Diabetes, Obesity and Metabolism, vol. 20, no. 5, pp. 1096-1101. https://doi.org/10.1111/dom.13216

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abstract = "Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.",

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T2 - Design, methods and baseline results

AU - Dorenbos, Elke

AU - Drummen, Mathijs

AU - Rijks, Jesse

AU - Adam, Tanja

AU - Stouthart, Pauline

AU - Martínez, J Alfredo

AU - Navas-Carretero, Santiago

AU - Stratton, Gareth

AU - Swindell, Nils

AU - Fogelholm, Mikael

AU - Raben, Anne

AU - Westerterp-Plantenga, Margriet

AU - Vreugdenhil, Anita

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N2 - Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.

AB - Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.

KW - Dietary intervention

KW - Insulin resistance

KW - Radomized trial

KW - Type 2 diabetes

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DO - 10.1111/dom.13216

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SN - 1462-8902

VL - 20

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JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

IS - 5

ER -

PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Abstract

Keywords

UN SDGs

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