PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Elke Dorenbos; Mathijs Drummen; Jesse Rijks; Tanja Adam; Pauline Stouthart; J Alfredo Martínez; Santiago Navas-Carretero; Gareth Stratton; Nils Swindell; Mikael Fogelholm; Anne Raben; Margriet Westerterp-Plantenga; Anita Vreugdenhil

doi:10.1111/dom.13216

PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Elke Dorenbos, Mathijs Drummen, Jesse Rijks, Tanja Adam, Pauline Stouthart, J Alfredo Martínez, Santiago Navas-Carretero, Gareth Stratton, Nils Swindell, Mikael Fogelholm, Anne Raben, Margriet Westerterp-Plantenga, Anita Vreugdenhil

Institut for Idræt og Ernæring - Fedmeforskning

3 Citationer (Scopus)

Abstract

Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.

Originalsprog	Engelsk
Tidsskrift	Diabetes, Obesity and Metabolism
Vol/bind	20
Udgave nummer	5
Sider (fra-til)	1096-1101
Antal sider	6
ISSN	1462-8902
DOI	https://doi.org/10.1111/dom.13216
Status	Udgivet - maj 2018

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10.1111/dom.13216

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Dorenbos, E., Drummen, M., Rijks, J., Adam, T., Stouthart, P., Martínez, J. A., Navas-Carretero, S., Stratton, G., Swindell, N., Fogelholm, M., Raben, A., Westerterp-Plantenga, M., & Vreugdenhil, A. (2018). PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results. Diabetes, Obesity and Metabolism, 20(5), 1096-1101. https://doi.org/10.1111/dom.13216

PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results. / Dorenbos, Elke; Drummen, Mathijs; Rijks, Jesse et al.
I: Diabetes, Obesity and Metabolism, Bind 20, Nr. 5, 05.2018, s. 1096-1101.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Dorenbos, E, Drummen, M, Rijks, J, Adam, T, Stouthart, P, Martínez, JA, Navas-Carretero, S, Stratton, G, Swindell, N, Fogelholm, M, Raben, A, Westerterp-Plantenga, M & Vreugdenhil, A 2018, 'PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results', Diabetes, Obesity and Metabolism, bind 20, nr. 5, s. 1096-1101. https://doi.org/10.1111/dom.13216

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title = "PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results",

abstract = "Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.",

keywords = "Dietary intervention, Insulin resistance, Radomized trial, Type 2 diabetes",

author = "Elke Dorenbos and Mathijs Drummen and Jesse Rijks and Tanja Adam and Pauline Stouthart and Mart{\'i}nez, {J Alfredo} and Santiago Navas-Carretero and Gareth Stratton and Nils Swindell and Mikael Fogelholm and Anne Raben and Margriet Westerterp-Plantenga and Anita Vreugdenhil",

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TY - JOUR

T1 - PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years

T2 - Design, methods and baseline results

AU - Dorenbos, Elke

AU - Drummen, Mathijs

AU - Rijks, Jesse

AU - Adam, Tanja

AU - Stouthart, Pauline

AU - Martínez, J Alfredo

AU - Navas-Carretero, Santiago

AU - Stratton, Gareth

AU - Swindell, Nils

AU - Fogelholm, Mikael

AU - Raben, Anne

AU - Westerterp-Plantenga, Margriet

AU - Vreugdenhil, Anita

N1 - CURIS 2018 NEXS 062

PY - 2018/5

Y1 - 2018/5

N2 - Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.

AB - Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) ≥2.0 and overweight/obesity. In 126 children (mean ± SD age 13.6 ± 2.2 years, body mass index [BMI] z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 ± 1.86 vs 3.23 ± 1.86; P =.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 ± 1.60, P =.004, and vs 3.40 ± 1.50, P <.001, respectively). IR was associated with sex, Tanner stage, BMI z-score and FM%. Fasting glucose concentrations were negatively associated with Baecke sport score (r = −0.223, P =.025) and positively with daytime sleepiness (r = 0.280, P =.016) independent of sex, Tanner stage, BMI z-score and FM%. In conclusion, IR was most severe in pubertal children with morbid obesity. The associations between fasting glucose concentration and Baecke sport score and sleepiness suggest these might be possible targets for diabetes prevention.

KW - Dietary intervention

KW - Insulin resistance

KW - Radomized trial

KW - Type 2 diabetes

U2 - 10.1111/dom.13216

DO - 10.1111/dom.13216

M3 - Journal article

C2 - 29322617

SN - 1462-8902

VL - 20

SP - 1096

EP - 1101

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

IS - 5

ER -

PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

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