Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.

Annelie Liljegren; Gail Barker; Faye Elliott; Lucio Bertario; Marie Luise Bisgaard; Diana Eccles; Gareth Evans; Finlay Macrae; Eamonn Maher; Annika Lindblom; Samuel Rotstein; Bo Nilsson; Jukka-Pekka Mecklin; Gabriela Möslein; Jeremy Jass; Riccardo Fodde; John Mathers; John Burn; D Timothy Bishop

doi:10.1200/JCO.2007.13.2795

Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.

Annelie Liljegren, Gail Barker, Faye Elliott, Lucio Bertario, Marie Luise Bisgaard, Diana Eccles, Gareth Evans, Finlay Macrae, Eamonn Maher, Annika Lindblom, Samuel Rotstein, Bo Nilsson, Jukka-Pekka Mecklin, Gabriela Möslein, Jeremy Jass, Riccardo Fodde, John Mathers, John Burn, D Timothy Bishop

Department of Cellular and Molecular Medicine

30 Citations (Scopus)

Abstract

PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.

Original language	English
Journal	Journal of Clinical Oncology
Volume	26
Issue number	20
Pages (from-to)	3434-9
Number of pages	5
ISSN	0732-183X
DOIs	https://doi.org/10.1200/JCO.2007.13.2795
Publication status	Published - 2008

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10.1200/JCO.2007.13.2795

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Liljegren, A., Barker, G., Elliott, F., Bertario, L., Bisgaard, M. L., Eccles, D., Evans, G., Macrae, F., Maher, E., Lindblom, A., Rotstein, S., Nilsson, B., Mecklin, J.-P., Möslein, G., Jass, J., Fodde, R., Mathers, J., Burn, J., & Bishop, D. T. (2008). Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. Journal of Clinical Oncology, 26(20), 3434-9. https://doi.org/10.1200/JCO.2007.13.2795

Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. / Liljegren, Annelie; Barker, Gail; Elliott, Faye et al.
In: Journal of Clinical Oncology, Vol. 26, No. 20, 2008, p. 3434-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Liljegren, A, Barker, G, Elliott, F, Bertario, L, Bisgaard, ML, Eccles, D, Evans, G, Macrae, F, Maher, E, Lindblom, A, Rotstein, S, Nilsson, B, Mecklin, J-P, Möslein, G, Jass, J, Fodde, R, Mathers, J, Burn, J & Bishop, DT 2008, 'Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.', Journal of Clinical Oncology, vol. 26, no. 20, pp. 3434-9. https://doi.org/10.1200/JCO.2007.13.2795

@article{459bb8608ede11dd86a6000ea68e967b,

title = "Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.",

abstract = "PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.",

author = "Annelie Liljegren and Gail Barker and Faye Elliott and Lucio Bertario and Bisgaard, {Marie Luise} and Diana Eccles and Gareth Evans and Finlay Macrae and Eamonn Maher and Annika Lindblom and Samuel Rotstein and Bo Nilsson and Jukka-Pekka Mecklin and Gabriela M{\"o}slein and Jeremy Jass and Riccardo Fodde and John Mathers and John Burn and Bishop, {D Timothy}",

note = "Keywords: Adenoma; Adult; Age Distribution; Aged; Analysis of Variance; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Cross-Sectional Studies; DNA Mismatch Repair; Female; Follow-Up Studies; Genetic Predisposition to Disease; Germ-Line Mutation; Heterozygote; Humans; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Neoplasm Staging; Prevalence; Proportional Hazards Models; Randomized Controlled Trials as Topic; Sex Distribution; Survival Analysis",

year = "2008",

doi = "10.1200/JCO.2007.13.2795",

language = "English",

volume = "26",

pages = "3434--9",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "American Society of Clinical Oncology",

number = "20",

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TY - JOUR

T1 - Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.

AU - Liljegren, Annelie

AU - Barker, Gail

AU - Elliott, Faye

AU - Bertario, Lucio

AU - Bisgaard, Marie Luise

AU - Eccles, Diana

AU - Evans, Gareth

AU - Macrae, Finlay

AU - Maher, Eamonn

AU - Lindblom, Annika

AU - Rotstein, Samuel

AU - Nilsson, Bo

AU - Mecklin, Jukka-Pekka

AU - Möslein, Gabriela

AU - Jass, Jeremy

AU - Fodde, Riccardo

AU - Mathers, John

AU - Burn, John

AU - Bishop, D Timothy

N1 - Keywords: Adenoma; Adult; Age Distribution; Aged; Analysis of Variance; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Cross-Sectional Studies; DNA Mismatch Repair; Female; Follow-Up Studies; Genetic Predisposition to Disease; Germ-Line Mutation; Heterozygote; Humans; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Neoplasm Staging; Prevalence; Proportional Hazards Models; Randomized Controlled Trials as Topic; Sex Distribution; Survival Analysis

PY - 2008

Y1 - 2008

N2 - PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.

AB - PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.

U2 - 10.1200/JCO.2007.13.2795

DO - 10.1200/JCO.2007.13.2795

M3 - Journal article

C2 - 18612159

SN - 0732-183X

VL - 26

SP - 3434

EP - 3439

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 20

ER -

Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.

Abstract

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