TY - JOUR
T1 - Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.
AU - Liljegren, Annelie
AU - Barker, Gail
AU - Elliott, Faye
AU - Bertario, Lucio
AU - Bisgaard, Marie Luise
AU - Eccles, Diana
AU - Evans, Gareth
AU - Macrae, Finlay
AU - Maher, Eamonn
AU - Lindblom, Annika
AU - Rotstein, Samuel
AU - Nilsson, Bo
AU - Mecklin, Jukka-Pekka
AU - Möslein, Gabriela
AU - Jass, Jeremy
AU - Fodde, Riccardo
AU - Mathers, John
AU - Burn, John
AU - Bishop, D Timothy
N1 - Keywords: Adenoma; Adult; Age Distribution; Aged; Analysis of Variance; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Cross-Sectional Studies; DNA Mismatch Repair; Female; Follow-Up Studies; Genetic Predisposition to Disease; Germ-Line Mutation; Heterozygote; Humans; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Neoplasm Staging; Prevalence; Proportional Hazards Models; Randomized Controlled Trials as Topic; Sex Distribution; Survival Analysis
PY - 2008
Y1 - 2008
N2 - PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.
AB - PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.
U2 - 10.1200/JCO.2007.13.2795
DO - 10.1200/JCO.2007.13.2795
M3 - Journal article
C2 - 18612159
SN - 0732-183X
VL - 26
SP - 3434
EP - 3439
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 20
ER -
