Preparation of a tritiated ginkgolide

Kristian Strømgaard; Makiko Suehiro; Koji Nakanishi

doi:10.1016/j.bmcl.2004.08.042

Preparation of a tritiated ginkgolide

Kristian Strømgaard, Makiko Suehiro, Koji Nakanishi

12 Citations (Scopus)

Abstract

Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	14
Issue number	22
Pages (from-to)	5673-5675
Number of pages	3
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2004.08.042
Publication status	Published - 15 Nov 2004

Keywords

Diterpenes
Ginkgo biloba
Ginkgolides
Lactones
Molecular Conformation
Tritium

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10.1016/j.bmcl.2004.08.042

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title = "Preparation of a tritiated ginkgolide",

abstract = "Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.",

keywords = "Diterpenes, Ginkgo biloba, Ginkgolides, Lactones, Molecular Conformation, Tritium",

author = "Kristian Str{\o}mgaard and Makiko Suehiro and Koji Nakanishi",

year = "2004",

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doi = "10.1016/j.bmcl.2004.08.042",

language = "English",

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journal = "Bioorganic & Medicinal Chemistry Letters",

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TY - JOUR

T1 - Preparation of a tritiated ginkgolide

AU - Strømgaard, Kristian

AU - Suehiro, Makiko

AU - Nakanishi, Koji

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

AB - Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

KW - Diterpenes

KW - Ginkgo biloba

KW - Ginkgolides

KW - Lactones

KW - Molecular Conformation

KW - Tritium

U2 - 10.1016/j.bmcl.2004.08.042

DO - 10.1016/j.bmcl.2004.08.042

M3 - Journal article

C2 - 15482945

SN - 0960-894X

VL - 14

SP - 5673

EP - 5675

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 22

ER -

Preparation of a tritiated ginkgolide

Abstract

Keywords

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