Preparation of a tritiated ginkgolide

TY - JOUR

T1 - Preparation of a tritiated ginkgolide

AU - Strømgaard, Kristian

AU - Suehiro, Makiko

AU - Nakanishi, Koji

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

AB - Ginkgolide B, a constituent of the tree Ginkgo biloba, was radiolabeled with the beta-emitter tritium ([(3)H]) in two steps from ginkgolide C. First, a triflate precursor was prepared utilizing the selective reactivity of 7-OH in ginkgolide C; the triflate was then reduced with sodium borotritide to yield tritiated ginkgolide B ([(3)H]GB) in good yield and high specific activity. The tritiated ginkgolide will be an important tool for studying neuromodulatory properties of ginkgolides.

KW - Diterpenes

KW - Ginkgo biloba

KW - Ginkgolides

KW - Lactones

KW - Molecular Conformation

KW - Tritium

U2 - 10.1016/j.bmcl.2004.08.042

DO - 10.1016/j.bmcl.2004.08.042

M3 - Journal article

C2 - 15482945

SN - 0960-894X

VL - 14

SP - 5673

EP - 5675

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 22

ER -