Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development

TY - JOUR

T1 - Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development

AU - Chang, Moonhee

AU - Lee, Dongheon

AU - Park, Hyesook

AU - Ha, Mina

AU - Hong, Yun-Chul

AU - Kim, Yangho

AU - Kim, Boong-Nyun

AU - Kim, Yeni

AU - Lim, Youn-Hee

AU - Ha, Eun-Hee

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2018/3/15

Y1 - 2018/3/15

N2 - Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pregnant participants was chosen from the prospective birth cohort study of Mother and Children's Environmental Health Study; MOCEH (N=1,751) from three regions of the Republic of Korea (Seoul, Cheon-an, and Ulsan). Participants were enrolled during their first trimester with informed consent. We investigated maternal characteristics including socio-economic and obstetrical history using questionnaires. An environmental hygienist measured participating mothers' personal TVOC exposure using passive samplers during pregnancy. Participants visited the research center at 6, 12, 24 and 36 months. At each visit, questionnaires about infantile environment and health conditions were answered and a neurobehavioral test (BSID-II) was conducted by certified investigators. We conducted multiple general linear and mixed model analyses to investigate the relationship between TVOC and infantile neurobehavioral development (SAS 9.3). Mean prenatal TVOC exposure was 284.2μg/m3. In longitudinal analyses on infantile neurobehavioral development, adjusted mean psychomotor development index and mental developmental index scores in high TVOC exposure group (cut off at Q3: 374.0 ug/m3) were 3 points lower than the low exposure group. Results suggested exposure to higher TVOC during the fetal period may adversely influence neurobehavioral development in the early life stage.

AB - Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pregnant participants was chosen from the prospective birth cohort study of Mother and Children's Environmental Health Study; MOCEH (N=1,751) from three regions of the Republic of Korea (Seoul, Cheon-an, and Ulsan). Participants were enrolled during their first trimester with informed consent. We investigated maternal characteristics including socio-economic and obstetrical history using questionnaires. An environmental hygienist measured participating mothers' personal TVOC exposure using passive samplers during pregnancy. Participants visited the research center at 6, 12, 24 and 36 months. At each visit, questionnaires about infantile environment and health conditions were answered and a neurobehavioral test (BSID-II) was conducted by certified investigators. We conducted multiple general linear and mixed model analyses to investigate the relationship between TVOC and infantile neurobehavioral development (SAS 9.3). Mean prenatal TVOC exposure was 284.2μg/m3. In longitudinal analyses on infantile neurobehavioral development, adjusted mean psychomotor development index and mental developmental index scores in high TVOC exposure group (cut off at Q3: 374.0 ug/m3) were 3 points lower than the low exposure group. Results suggested exposure to higher TVOC during the fetal period may adversely influence neurobehavioral development in the early life stage.

KW - Adult

KW - Child Development/drug effects

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Maternal Exposure/adverse effects

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects/physiopathology

KW - Prospective Studies

KW - Republic of Korea

KW - Seoul

KW - Volatile Organic Compounds/adverse effects

U2 - 10.1016/j.scitotenv.2017.09.046

DO - 10.1016/j.scitotenv.2017.09.046

M3 - Journal article

C2 - 29153381

SN - 0048-9697

VL - 618

SP - 977

EP - 981

JO - The Science of the Total Environment

JF - The Science of the Total Environment

ER -