Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening

TY - JOUR

T1 - Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening

AU - Jørgensen, Ditte E S

AU - Vejlstrup, Niels

AU - Jørgensen, Connie

AU - Maroun, Lisa Leth

AU - Steensberg, Jesper

AU - Hessellund, Anette

AU - Jørgensen, Finn Stener

AU - Larsen, Torben

AU - Shalmi, Anne-Cathrine

AU - Skibsted, Lillian

AU - Zingenberg, Helle

AU - Ekelund, Charlotte

AU - Tabor, Ann

N1 - © 2014 John Wiley & Sons, Ltd.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objectives: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark. Methods: Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness. Results: Out of 86121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95th percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21. Conclusions: Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies.

AB - Objectives: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark. Methods: Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness. Results: Out of 86121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95th percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21. Conclusions: Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies.

U2 - 10.1002/pd.4525

DO - 10.1002/pd.4525

M3 - Journal article

C2 - 25352400

SN - 0197-3851

VL - 35

SP - 325

EP - 330

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 4

ER -