Pregnancy-associated plasma protein-A and the vulnerable plaque

Camilla H B Jespersen; Kirstine R Vestergaard; Morten Schou; Børge Teisner; Jens P Goetze; Kasper Iversen

doi:10.2217/bmm.14.53

Pregnancy-associated plasma protein-A and the vulnerable plaque

Camilla H B Jespersen, Kirstine R Vestergaard, Morten Schou, Børge Teisner, Jens P Goetze, Kasper Iversen

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

For more than a decade, pregnancy-associated plasma protein-A (PAPP-A) has been examined for its relation to acute coronary syndrome (ACS) and the vulnerable plaque. This review summarizes the current knowledge of plasma PAPP-A in relation to nonpregnant individuals focusing on patients with ACS, discusses its use as a possible biomarker for diagnosis and prognosis in ACS, briefly describes the challenges in different assay technologies and describes the effect of heparin administration on PAPP-A concentrations in plasma.

Original language	English
Journal	Biomarkers in Medicine
Volume	8
Issue number	8
Pages (from-to)	1033-47
Number of pages	15
ISSN	1752-0363
DOIs	https://doi.org/10.2217/bmm.14.53
Publication status	Published - 1 Aug 2014

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10.2217/bmm.14.53

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AU - Vestergaard, Kirstine R

AU - Schou, Morten

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AU - Goetze, Jens P

AU - Iversen, Kasper

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AB - For more than a decade, pregnancy-associated plasma protein-A (PAPP-A) has been examined for its relation to acute coronary syndrome (ACS) and the vulnerable plaque. This review summarizes the current knowledge of plasma PAPP-A in relation to nonpregnant individuals focusing on patients with ACS, discusses its use as a possible biomarker for diagnosis and prognosis in ACS, briefly describes the challenges in different assay technologies and describes the effect of heparin administration on PAPP-A concentrations in plasma.

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Pregnancy-associated plasma protein-A and the vulnerable plaque

Abstract

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