Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial

Lone Petersen; Anne Thorup; Johan Øqhlenschlaeger; Torben Øqstergaard Christensen; Pia Jeppesen; Gertrud Krarup; Per Jørrgensen; Erik Lykke Mortensen; Merete Nordentoft; Lone Petersen; Anne Thorup; Johan Øqhlenschlaeger; Torben Øqstergaard Christensen; Pia Jeppesen; Gertrud Krarup; Per Jørrgensen; Erik Lykke Mortensen; Merete Nordentoft

Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial

Lone Petersen, Anne Thorup, Johan Øqhlenschlaeger, Torben Øqstergaard Christensen, Pia Jeppesen, Gertrud Krarup, Per Jørrgensen, Erik Lykke Mortensen, Merete Nordentoft, Lone Petersen, Anne Thorup, Johan Øqhlenschlaeger, Torben Øqstergaard Christensen, Pia Jeppesen, Gertrud Krarup, Per Jørrgensen, Erik Lykke Mortensen, Merete Nordentoft

74 Citations (Scopus)

Abstract

OBJECTIVE: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). METHOD: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. RESULTS: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. CONCLUSIONS: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.

Original language	English
Journal	Canadian Journal of Psychiatry
Volume	53
Issue number	10
Pages (from-to)	660-70
Number of pages	11
ISSN	0706-7437
Publication status	Published - 2008

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Petersen, L., Thorup, A., Øqhlenschlaeger, J., Christensen, T. Ø., Jeppesen, P., Krarup, G., Jørrgensen, P., Mortensen, E. L., Nordentoft, M., Petersen, L., Thorup, A., Øqhlenschlaeger, J., Christensen, T. Ø., Jeppesen, P., Krarup, G., Jørrgensen, P., Mortensen, E. L., & Nordentoft, M. (2008). Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial. Canadian Journal of Psychiatry, 53(10), 660-70.

Petersen, L, Thorup, A, Øqhlenschlaeger, J, Christensen, TØ, Jeppesen, P, Krarup, G, Jørrgensen, P, Mortensen, EL , Nordentoft, M, Petersen, L, Thorup, A, Øqhlenschlaeger, J, Christensen, TØ, Jeppesen, P, Krarup, G, Jørrgensen, P, Mortensen, EL & Nordentoft, M 2008, 'Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial', Canadian Journal of Psychiatry, vol. 53, no. 10, pp. 660-70.

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title = "Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial",

abstract = "OBJECTIVE: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). METHOD: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. RESULTS: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. CONCLUSIONS: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.",

author = "Lone Petersen and Anne Thorup and Johan {\O}qhlenschlaeger and Christensen, {Torben {\O}qstergaard} and Pia Jeppesen and Gertrud Krarup and Per J{\o}rrgensen and Mortensen, {Erik Lykke} and Merete Nordentoft and Lone Petersen and Anne Thorup and Johan {\O}qhlenschlaeger and Christensen, {Torben {\O}qstergaard} and Pia Jeppesen and Gertrud Krarup and Per J{\o}rrgensen and Mortensen, {Erik Lykke} and Merete Nordentoft",

note = "Keywords: Adult; Cohort Studies; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Denmark; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Psychotherapy; Psychotropic Drugs; Schizophrenia; Schizophrenic Psychology; Substance-Related Disorders; Young Adult",

year = "2008",

language = "English",

volume = "53",

pages = "660--70",

journal = "Canadian Journal of Psychiatry",

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T1 - Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial

AU - Petersen, Lone

AU - Thorup, Anne

AU - Øqhlenschlaeger, Johan

AU - Christensen, Torben Øqstergaard

AU - Jeppesen, Pia

AU - Krarup, Gertrud

AU - Jørrgensen, Per

AU - Mortensen, Erik Lykke

AU - Nordentoft, Merete

AU - Petersen, Lone

AU - Thorup, Anne

AU - Øqhlenschlaeger, Johan

AU - Christensen, Torben Øqstergaard

AU - Jeppesen, Pia

AU - Krarup, Gertrud

AU - Jørrgensen, Per

AU - Mortensen, Erik Lykke

AU - Nordentoft, Merete

N1 - Keywords: Adult; Cohort Studies; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Denmark; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Psychotherapy; Psychotropic Drugs; Schizophrenia; Schizophrenic Psychology; Substance-Related Disorders; Young Adult

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). METHOD: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. RESULTS: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. CONCLUSIONS: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.

AB - OBJECTIVE: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). METHOD: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. RESULTS: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. CONCLUSIONS: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.

M3 - Journal article

SN - 0706-7437

VL - 53

SP - 660

EP - 670

JO - Canadian Journal of Psychiatry

JF - Canadian Journal of Psychiatry

IS - 10

ER -

Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial

Abstract

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