TY - JOUR
T1 - Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial
AU - Petersen, Lone
AU - Thorup, Anne
AU - Øqhlenschlaeger, Johan
AU - Christensen, Torben Øqstergaard
AU - Jeppesen, Pia
AU - Krarup, Gertrud
AU - Jørrgensen, Per
AU - Mortensen, Erik Lykke
AU - Nordentoft, Merete
AU - Petersen, Lone
AU - Thorup, Anne
AU - Øqhlenschlaeger, Johan
AU - Christensen, Torben Øqstergaard
AU - Jeppesen, Pia
AU - Krarup, Gertrud
AU - Jørrgensen, Per
AU - Mortensen, Erik Lykke
AU - Nordentoft, Merete
N1 - Keywords: Adult; Cohort Studies; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Denmark; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Psychotherapy; Psychotropic Drugs; Schizophrenia; Schizophrenic Psychology; Substance-Related Disorders; Young Adult
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). METHOD: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. RESULTS: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. CONCLUSIONS: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.
AB - OBJECTIVE: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). METHOD: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables, diagnosis, duration of untreated psychosis (DUP), premorbid functioning, psychotic and negative symptoms, substance abuse, adherence to medication, and service use. ORs were calculated with logistic regression analyses. RESULTS: A total of 369 patients (67%) participated in the follow-up interview. After 2 years, 36% remitted and 17% were considered fully recovered. Full recovery was associated with shorter DUP, better premorbid adjustment, fewer negative symptoms at baseline, no substance abuse at baseline, and adherence to medication and OPUS treatment. CONCLUSIONS: Several predictive factors were identified, and focus should be on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome, for example, patients with a substance abuse problem and poor premorbid adjustment.
M3 - Journal article
SN - 0706-7437
VL - 53
SP - 660
EP - 670
JO - Canadian Journal of Psychiatry
JF - Canadian Journal of Psychiatry
IS - 10
ER -
