Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces

Stanislav Jelavic; Dominique Jeanette Tobler; Tue Hassenkam; J. J. De Yoreo; Susan Louise Svane Stipp; Karina Krarup Sand

doi:10.1039/c7cc04276k

Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces

Stanislav Jelavic, Dominique Jeanette Tobler, Tue Hassenkam, J. J. De Yoreo, Susan Louise Svane Stipp, Karina Krarup Sand

Department of Chemistry

7 Citations (Scopus)

Abstract

We measured the binding energy and bonding parameters between model nucleotide functional groups and model clay mineral surfaces in solutions of acidic pH. We demonstrate that basal surfaces of clay minerals interact most strongly with nucleobases and show that the adsorption of the phosphate group to clay edges could facilitate polymerisation. Our results suggest that Al- and Fe-rich edge sites behave similarly in nucleotide polymerisation through change of the phosphodiester bond strength. We present an internally consistent set of thermodynamic parameters that represent the nucleotide–clay mineral system.

Original language	English
Journal	Chemical Communications
Volume	53
Issue number	94
Pages (from-to)	12700-12703
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c7cc04276k
Publication status	Published - 2017

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10.1039/c7cc04276k

Cite this

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title = "Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces",

abstract = "We measured the binding energy and bonding parameters between model nucleotide functional groups and model clay mineral surfaces in solutions of acidic pH. We demonstrate that basal surfaces of clay minerals interact most strongly with nucleobases and show that the adsorption of the phosphate group to clay edges could facilitate polymerisation. Our results suggest that Al- and Fe-rich edge sites behave similarly in nucleotide polymerisation through change of the phosphodiester bond strength. We present an internally consistent set of thermodynamic parameters that represent the nucleotide–clay mineral system.",

author = "Stanislav Jelavic and Tobler, {Dominique Jeanette} and Tue Hassenkam and {De Yoreo}, {J. J.} and Stipp, {Susan Louise Svane} and Sand, {Karina Krarup}",

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language = "English",

volume = "53",

pages = "12700--12703",

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publisher = "Royal Society of Chemistry",

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T1 - Prebiotic RNA polymerisation

T2 - energetics of nucleotide adsorption and polymerisation on clay mineral surfaces

AU - Jelavic, Stanislav

AU - Tobler, Dominique Jeanette

AU - Hassenkam, Tue

AU - De Yoreo, J. J.

AU - Stipp, Susan Louise Svane

AU - Sand, Karina Krarup

PY - 2017

Y1 - 2017

N2 - We measured the binding energy and bonding parameters between model nucleotide functional groups and model clay mineral surfaces in solutions of acidic pH. We demonstrate that basal surfaces of clay minerals interact most strongly with nucleobases and show that the adsorption of the phosphate group to clay edges could facilitate polymerisation. Our results suggest that Al- and Fe-rich edge sites behave similarly in nucleotide polymerisation through change of the phosphodiester bond strength. We present an internally consistent set of thermodynamic parameters that represent the nucleotide–clay mineral system.

AB - We measured the binding energy and bonding parameters between model nucleotide functional groups and model clay mineral surfaces in solutions of acidic pH. We demonstrate that basal surfaces of clay minerals interact most strongly with nucleobases and show that the adsorption of the phosphate group to clay edges could facilitate polymerisation. Our results suggest that Al- and Fe-rich edge sites behave similarly in nucleotide polymerisation through change of the phosphodiester bond strength. We present an internally consistent set of thermodynamic parameters that represent the nucleotide–clay mineral system.

U2 - 10.1039/c7cc04276k

DO - 10.1039/c7cc04276k

M3 - Journal article

C2 - 29134988

SN - 1359-7345

VL - 53

SP - 12700

EP - 12703

JO - Chemical Communications

JF - Chemical Communications

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ER -