Pre-metastatic niches: Organ-specific homes for metastases

Héctor Peinado; Haiying Zhang; Irina R. Matei; Bruno Costa-Silva; Ayuko Hoshino; Goncalo Rodrigues; Bethan Psaila; Rosandra N. Kaplan; Jacqueline F. Bromberg; Yibin Kang; Mina J. Bissell; Thomas R. Cox; Amato J. Giaccia; Janine T. Erler; Sachie Hiratsuka; Cyrus M. Ghajar; David Lyden

doi:10.1038/nrc.2017.6

Pre-metastatic niches: Organ-specific homes for metastases

Héctor Peinado, Haiying Zhang, Irina R. Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline F. Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar, David Lyden^*

^*Corresponding author for this work

568 Citations (Scopus)

Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Original language	English
Journal	Nature Reviews Cancer
Volume	17
Issue number	5
Pages (from-to)	302-317
Number of pages	16
ISSN	1474-175X
DOIs	https://doi.org/10.1038/nrc.2017.6
Publication status	Published - 1 May 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nrc.2017.6

Cite this

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., Bissell, M. J., Cox, T. R., Giaccia, A. J., Erler, J. T., Hiratsuka, S., Ghajar, C. M., & Lyden, D. (2017). Pre-metastatic niches: Organ-specific homes for metastases. Nature Reviews Cancer, 17(5), 302-317. https://doi.org/10.1038/nrc.2017.6

@article{45ba04092eb0413390ec1c26a485d93a,

title = "Pre-metastatic niches: Organ-specific homes for metastases",

abstract = "It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.",

author = "H{\'e}ctor Peinado and Haiying Zhang and Matei, {Irina R.} and Bruno Costa-Silva and Ayuko Hoshino and Goncalo Rodrigues and Bethan Psaila and Kaplan, {Rosandra N.} and Bromberg, {Jacqueline F.} and Yibin Kang and Bissell, {Mina J.} and Cox, {Thomas R.} and Giaccia, {Amato J.} and Erler, {Janine T.} and Sachie Hiratsuka and Ghajar, {Cyrus M.} and David Lyden",

year = "2017",

month = may,

day = "1",

doi = "10.1038/nrc.2017.6",

language = "English",

volume = "17",

pages = "302--317",

journal = "Nature Reviews. Cancer",

issn = "1474-175X",

publisher = "nature publishing group",

number = "5",

}

TY - JOUR

T1 - Pre-metastatic niches

T2 - Organ-specific homes for metastases

AU - Peinado, Héctor

AU - Zhang, Haiying

AU - Matei, Irina R.

AU - Costa-Silva, Bruno

AU - Hoshino, Ayuko

AU - Rodrigues, Goncalo

AU - Psaila, Bethan

AU - Kaplan, Rosandra N.

AU - Bromberg, Jacqueline F.

AU - Kang, Yibin

AU - Bissell, Mina J.

AU - Cox, Thomas R.

AU - Giaccia, Amato J.

AU - Erler, Janine T.

AU - Hiratsuka, Sachie

AU - Ghajar, Cyrus M.

AU - Lyden, David

PY - 2017/5/1

Y1 - 2017/5/1

N2 - It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

AB - It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

U2 - 10.1038/nrc.2017.6

DO - 10.1038/nrc.2017.6

M3 - Review

C2 - 28303905

AN - SCOPUS:85015629030

SN - 1474-175X

VL - 17

SP - 302

EP - 317

JO - Nature Reviews. Cancer

JF - Nature Reviews. Cancer

IS - 5

ER -

Pre-metastatic niches: Organ-specific homes for metastases

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this