Pre-metastatic niches: Organ-specific homes for metastases

Héctor Peinado; Haiying Zhang; Irina R. Matei; Bruno Costa-Silva; Ayuko Hoshino; Goncalo Rodrigues; Bethan Psaila; Rosandra N. Kaplan; Jacqueline F. Bromberg; Yibin Kang; Mina J. Bissell; Thomas R. Cox; Amato J. Giaccia; Janine T. Erler; Sachie Hiratsuka; Cyrus M. Ghajar; David Lyden

doi:10.1038/nrc.2017.6

Pre-metastatic niches: Organ-specific homes for metastases

Héctor Peinado, Haiying Zhang, Irina R. Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline F. Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar, David Lyden^*

^*Corresponding author af dette arbejde

568 Citationer (Scopus)

Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews Cancer
Vol/bind	17
Udgave nummer	5
Sider (fra-til)	302-317
Antal sider	16
ISSN	1474-175X
DOI	https://doi.org/10.1038/nrc.2017.6
Status	Udgivet - 1 maj 2017

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Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., Bissell, M. J., Cox, T. R., Giaccia, A. J., Erler, J. T., Hiratsuka, S., Ghajar, C. M., & Lyden, D. (2017). Pre-metastatic niches: Organ-specific homes for metastases. Nature Reviews Cancer, 17(5), 302-317. https://doi.org/10.1038/nrc.2017.6

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author = "H{\'e}ctor Peinado and Haiying Zhang and Matei, {Irina R.} and Bruno Costa-Silva and Ayuko Hoshino and Goncalo Rodrigues and Bethan Psaila and Kaplan, {Rosandra N.} and Bromberg, {Jacqueline F.} and Yibin Kang and Bissell, {Mina J.} and Cox, {Thomas R.} and Giaccia, {Amato J.} and Erler, {Janine T.} and Sachie Hiratsuka and Ghajar, {Cyrus M.} and David Lyden",

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AU - Peinado, Héctor

AU - Zhang, Haiying

AU - Matei, Irina R.

AU - Costa-Silva, Bruno

AU - Hoshino, Ayuko

AU - Rodrigues, Goncalo

AU - Psaila, Bethan

AU - Kaplan, Rosandra N.

AU - Bromberg, Jacqueline F.

AU - Kang, Yibin

AU - Bissell, Mina J.

AU - Cox, Thomas R.

AU - Giaccia, Amato J.

AU - Erler, Janine T.

AU - Hiratsuka, Sachie

AU - Ghajar, Cyrus M.

AU - Lyden, David

PY - 2017/5/1

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N2 - It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

AB - It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

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JF - Nature Reviews Cancer

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Pre-metastatic niches: Organ-specific homes for metastases

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