Postnatal hematopoiesis and gut microbiota in NOD mice deviate from C57BL/6 mice

Dina Silke Malling Damlund; Stine Broeng Metzdorff; Jane Preuss Hasselby; Maria Wiese; Mia Thorup Lundsager; Dennis Sandris Nielsen; Karsten Stig Buschard; Axel Kornerup Hansen; Hanne Frøkiær

doi:10.1155/2016/6321980

Postnatal hematopoiesis and gut microbiota in NOD mice deviate from C57BL/6 mice

Dina Silke Malling Damlund, Stine Broeng Metzdorff, Jane Preuss Hasselby, Maria Wiese, Mia Thorup Lundsager, Dennis Sandris Nielsen, Karsten Stig Buschard, Axel Kornerup Hansen, Hanne Frøkiær

Food Microbiology, Gut Health, and Fermentation

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Abstract

Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice. The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions. A distinct bacteria profile rich in staphylococci was found at postnatal days (PND) 1-4 in NOD mice. Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.

Original language	English
Article number	6321980
Journal	Journal of Diabetes Research
Volume	2016
Number of pages	15
ISSN	2314-6745
DOIs	https://doi.org/10.1155/2016/6321980
Publication status	Published - 2016

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title = "Postnatal hematopoiesis and gut microbiota in NOD mice deviate from C57BL/6 mice",

abstract = "Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice. The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions. A distinct bacteria profile rich in staphylococci was found at postnatal days (PND) 1-4 in NOD mice. Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.",

author = "Damlund, {Dina Silke Malling} and Metzdorff, {Stine Broeng} and Hasselby, {Jane Preuss} and Maria Wiese and Lundsager, {Mia Thorup} and Nielsen, {Dennis Sandris} and Buschard, {Karsten Stig} and Hansen, {Axel Kornerup} and Hanne Fr{\o}ki{\ae}r",

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doi = "10.1155/2016/6321980",

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AU - Damlund, Dina Silke Malling

AU - Metzdorff, Stine Broeng

AU - Hasselby, Jane Preuss

AU - Wiese, Maria

AU - Lundsager, Mia Thorup

AU - Nielsen, Dennis Sandris

AU - Buschard, Karsten Stig

AU - Hansen, Axel Kornerup

AU - Frøkiær, Hanne

PY - 2016

Y1 - 2016

N2 - Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice. The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions. A distinct bacteria profile rich in staphylococci was found at postnatal days (PND) 1-4 in NOD mice. Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.

AB - Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice. The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions. A distinct bacteria profile rich in staphylococci was found at postnatal days (PND) 1-4 in NOD mice. Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.

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DO - 10.1155/2016/6321980

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JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

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ER -

Postnatal hematopoiesis and gut microbiota in NOD mice deviate from C57BL/6 mice

Abstract

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