Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

Anne Fog Lomholt; Camilla Frederiksen; Ib Jarle Christensen; Nils Brünner; Hans Jørgen Nielsen

doi:10.1016/j.cca.2007.01.022

Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

Anne Fog Lomholt, Camilla Frederiksen, Ib Jarle Christensen, Nils Brünner, Hans Jørgen Nielsen

Department of Clinical Medicine

33 Citations (Scopus)

Abstract

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.

Original language	English
Journal	Clinica Chimica Acta
Volume	380
Issue number	1-2
Pages (from-to)	128-32
Number of pages	5
ISSN	0009-8981
DOIs	https://doi.org/10.1016/j.cca.2007.01.022
Publication status	Published - 2007

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10.1016/j.cca.2007.01.022

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abstract = "Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.",

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AU - Lomholt, Anne Fog

AU - Frederiksen, Camilla

AU - Christensen, Ib Jarle

AU - Brünner, Nils

AU - Nielsen, Hans Jørgen

PY - 2007

Y1 - 2007

N2 - Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.

AB - Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.

U2 - 10.1016/j.cca.2007.01.022

DO - 10.1016/j.cca.2007.01.022

M3 - Journal article

SN - 0009-8981

VL - 380

SP - 128

EP - 132

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 1-2

ER -

Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

Abstract

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