Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

Anne Fog Lomholt; Camilla Frederiksen; Ib Jarle Christensen; Nils Brünner; Hans Jørgen Nielsen

doi:http://dx.doi.org/10.1016/j.cca.2007.01.022

Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

Anne Fog Lomholt, Camilla Frederiksen, Ib Jarle Christensen, Nils Brünner, Hans Jørgen Nielsen

Institut for Klinisk Medicin

33 Citationer (Scopus)

Abstract

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.

Originalsprog	Engelsk
Tidsskrift	Clinica Chimica Acta
Vol/bind	380
Udgave nummer	1-2
Sider (fra-til)	128-32
Antal sider	5
ISSN	0009-8981
DOI	https://doi.org/10.1016/j.cca.2007.01.022
Status	Udgivet - 2007

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http://dx.doi.org/10.1016/j.cca.2007.01.022

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title = "Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations",

abstract = "Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.",

author = "Lomholt, {Anne Fog} and Camilla Frederiksen and Christensen, {Ib Jarle} and Nils Br{\"u}nner and Nielsen, {Hans J{\o}rgen}",

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T1 - Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

AU - Lomholt, Anne Fog

AU - Frederiksen, Camilla

AU - Christensen, Ib Jarle

AU - Brünner, Nils

AU - Nielsen, Hans Jørgen

PY - 2007

Y1 - 2007

N2 - Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.

AB - Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.

U2 - http://dx.doi.org/10.1016/j.cca.2007.01.022

DO - http://dx.doi.org/10.1016/j.cca.2007.01.022

M3 - Journal article

SN - 0009-8981

VL - 380

SP - 128

EP - 132

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 1-2

ER -

Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations

Abstract

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