Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

S L Asa; K Kovacs; L Stefaneanu; E Horvath; Nils Billestrup; C Gonzalez-Manchon; W Vale

Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

S L Asa, K Kovacs, L Stefaneanu, E Horvath, Nils Billestrup, C Gonzalez-Manchon, W Vale

53 Citations (Scopus)

Abstract

It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

Original language	English
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Volume	193
Issue number	3
Pages (from-to)	232-5
Number of pages	4
ISSN	0037-9727
Publication status	Published - Mar 1990

Keywords

Adenoma
Aging
Animals
Growth Hormone
Growth Hormone-Releasing Hormone
Humans
Hyperplasia
Mice
Mice, Transgenic
Pituitary Gland
Pituitary Neoplasms
Prolactin

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Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. / Asa, S L; Kovacs, K; Stefaneanu, L et al.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), Vol. 193, No. 3, 03.1990, p. 232-5.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.",

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AU - Asa, S L

AU - Kovacs, K

AU - Stefaneanu, L

AU - Horvath, E

AU - Billestrup, Nils

AU - Gonzalez-Manchon, C

AU - Vale, W

PY - 1990/3

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N2 - It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

AB - It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

KW - Adenoma

KW - Aging

KW - Animals

KW - Growth Hormone

KW - Growth Hormone-Releasing Hormone

KW - Humans

KW - Hyperplasia

KW - Mice

KW - Mice, Transgenic

KW - Pituitary Gland

KW - Pituitary Neoplasms

KW - Prolactin

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SN - 0037-9727

VL - 193

SP - 232

EP - 235

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

IS - 3

ER -

Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

Abstract

Keywords

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