Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

S L Asa; K Kovacs; L Stefaneanu; E Horvath; Nils Billestrup; C Gonzalez-Manchon; W Vale

Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

S L Asa, K Kovacs, L Stefaneanu, E Horvath, Nils Billestrup, C Gonzalez-Manchon, W Vale

53 Citationer (Scopus)

Abstract

It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

Originalsprog	Engelsk
Tidsskrift	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Vol/bind	193
Udgave nummer	3
Sider (fra-til)	232-5
Antal sider	4
ISSN	0037-9727
Status	Udgivet - mar. 1990

Citationsformater

Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. / Asa, S L; Kovacs, K; Stefaneanu, L et al.
I: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), Bind 193, Nr. 3, 03.1990, s. 232-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.",

keywords = "Adenoma, Aging, Animals, Growth Hormone, Growth Hormone-Releasing Hormone, Humans, Hyperplasia, Mice, Mice, Transgenic, Pituitary Gland, Pituitary Neoplasms, Prolactin",

author = "Asa, {S L} and K Kovacs and L Stefaneanu and E Horvath and Nils Billestrup and C Gonzalez-Manchon and W Vale",

year = "1990",

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T1 - Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

AU - Asa, S L

AU - Kovacs, K

AU - Stefaneanu, L

AU - Horvath, E

AU - Billestrup, Nils

AU - Gonzalez-Manchon, C

AU - Vale, W

PY - 1990/3

Y1 - 1990/3

N2 - It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

AB - It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.

KW - Adenoma

KW - Aging

KW - Animals

KW - Growth Hormone

KW - Growth Hormone-Releasing Hormone

KW - Humans

KW - Hyperplasia

KW - Mice

KW - Mice, Transgenic

KW - Pituitary Gland

KW - Pituitary Neoplasms

KW - Prolactin

M3 - Journal article

C2 - 2106141

SN - 0037-9727

VL - 193

SP - 232

EP - 235

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

IS - 3

ER -

Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone

Abstract

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