Photoreceptor atrophy in acute zonal occult outer retinopathy

N. Zibrandtsen; I.C. Munch; K. Klemp; T.M. Jorgensen; B. Sander; Michael Larsen

Photoreceptor atrophy in acute zonal occult outer retinopathy

N. Zibrandtsen, I.C. Munch, K. Klemp, T.M. Jorgensen, B. Sander, Michael Larsen

31 Citations (Scopus)

Abstract

PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes. METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG). RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss. CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions
Udgivelsesdato: 2008/12

Original language	English
Journal	Acta Ophthalmologica Scandinavica
Volume	86
Issue number	8
Pages (from-to)	913-916
Number of pages	3
ISSN	1395-3907
Publication status	Published - 2008

Cite this

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title = "Photoreceptor atrophy in acute zonal occult outer retinopathy",

abstract = "PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes. METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG). RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss. CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions Udgivelsesdato: 2008/12",

author = "N. Zibrandtsen and I.C. Munch and K. Klemp and T.M. Jorgensen and B. Sander and Michael Larsen",

year = "2008",

language = "English",

volume = "86",

pages = "913--916",

journal = "Acta Ophthalmologica",

issn = "1755-375X",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Photoreceptor atrophy in acute zonal occult outer retinopathy

AU - Zibrandtsen, N.

AU - Munch, I.C.

AU - Klemp, K.

AU - Jorgensen, T.M.

AU - Sander, B.

AU - Larsen, Michael

PY - 2008

Y1 - 2008

N2 - PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes. METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG). RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss. CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions Udgivelsesdato: 2008/12

AB - PURPOSE: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes. METHODS: Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG). RESULTS: Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss. CONCLUSION: Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions Udgivelsesdato: 2008/12

M3 - Journal article

SN - 1755-375X

VL - 86

SP - 913

EP - 916

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

IS - 8

ER -