Phospho.ELM: a database of phosphorylation sites--update 2011

Holger Dinkel; Claudia Chica; Allegra Via; Cathryn M Gould; Lars J Jensen; Toby J Gibson; Francesca Diella

doi:10.1093/nar/gkq1104

Phospho.ELM: a database of phosphorylation sites--update 2011

Holger Dinkel, Claudia Chica, Allegra Via, Cathryn M Gould, Lars J Jensen, Toby J Gibson, Francesca Diella

398 Citations (Scopus)

Abstract

The Phospho.ELM resource (http://phospho.elm.eu.org) is a relational database designed to store in vivo and in vitro phosphorylation data extracted from the scientific literature and phosphoproteomic analyses. The resource has been actively developed for more than 7 years and currently comprises 42,574 serine, threonine and tyrosine non-redundant phosphorylation sites. Several new features have been implemented, such as structural disorder/order and accessibility information and a conservation score. Additionally, the conservation of the phosphosites can now be visualized directly on the multiple sequence alignment used for the score calculation. Finally, special emphasis has been put on linking to external resources such as interaction networks and other databases.

Original language	English
Book series	Nucleic Acids Symposium Series
Volume	39
Issue number	Database issue
Pages (from-to)	D261-7
ISSN	0261-3166
DOIs	https://doi.org/10.1093/nar/gkq1104
Publication status	Published - 1 Jan 2011

Keywords

Amino Acid Sequence
Animals
Conserved Sequence
Databases, Protein
Humans
Mice
Phosphoproteins
Phosphorylation
Protein Conformation
Sequence Analysis, Protein
Serine
Threonine
Tyrosine

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title = "Phospho.ELM: a database of phosphorylation sites--update 2011",

abstract = "The Phospho.ELM resource (http://phospho.elm.eu.org) is a relational database designed to store in vivo and in vitro phosphorylation data extracted from the scientific literature and phosphoproteomic analyses. The resource has been actively developed for more than 7 years and currently comprises 42,574 serine, threonine and tyrosine non-redundant phosphorylation sites. Several new features have been implemented, such as structural disorder/order and accessibility information and a conservation score. Additionally, the conservation of the phosphosites can now be visualized directly on the multiple sequence alignment used for the score calculation. Finally, special emphasis has been put on linking to external resources such as interaction networks and other databases.",

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author = "Holger Dinkel and Claudia Chica and Allegra Via and Gould, {Cathryn M} and Jensen, {Lars J} and Gibson, {Toby J} and Francesca Diella",

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T1 - Phospho.ELM: a database of phosphorylation sites--update 2011

AU - Dinkel, Holger

AU - Chica, Claudia

AU - Via, Allegra

AU - Gould, Cathryn M

AU - Jensen, Lars J

AU - Gibson, Toby J

AU - Diella, Francesca

PY - 2011/1/1

Y1 - 2011/1/1

N2 - The Phospho.ELM resource (http://phospho.elm.eu.org) is a relational database designed to store in vivo and in vitro phosphorylation data extracted from the scientific literature and phosphoproteomic analyses. The resource has been actively developed for more than 7 years and currently comprises 42,574 serine, threonine and tyrosine non-redundant phosphorylation sites. Several new features have been implemented, such as structural disorder/order and accessibility information and a conservation score. Additionally, the conservation of the phosphosites can now be visualized directly on the multiple sequence alignment used for the score calculation. Finally, special emphasis has been put on linking to external resources such as interaction networks and other databases.

AB - The Phospho.ELM resource (http://phospho.elm.eu.org) is a relational database designed to store in vivo and in vitro phosphorylation data extracted from the scientific literature and phosphoproteomic analyses. The resource has been actively developed for more than 7 years and currently comprises 42,574 serine, threonine and tyrosine non-redundant phosphorylation sites. Several new features have been implemented, such as structural disorder/order and accessibility information and a conservation score. Additionally, the conservation of the phosphosites can now be visualized directly on the multiple sequence alignment used for the score calculation. Finally, special emphasis has been put on linking to external resources such as interaction networks and other databases.

KW - Amino Acid Sequence

KW - Animals

KW - Conserved Sequence

KW - Databases, Protein

KW - Humans

KW - Mice

KW - Phosphoproteins

KW - Phosphorylation

KW - Protein Conformation

KW - Sequence Analysis, Protein

KW - Serine

KW - Threonine

KW - Tyrosine

U2 - 10.1093/nar/gkq1104

DO - 10.1093/nar/gkq1104

M3 - Journal article

C2 - 21062810

SN - 0261-3166

VL - 39

SP - D261-7

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

IS - Database issue

ER -

Phospho.ELM: a database of phosphorylation sites--update 2011

Abstract

Keywords

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