Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Wang Hengzhuang; Hong Wu; Oana Ciofu; Zhijun Song; Niels Høiby; Hengzhuang Wang

doi:10.1128/AAC.00126-11

Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Wang Hengzhuang, Hong Wu, Oana Ciofu, Zhijun Song, Niels Høiby, Hengzhuang Wang

114 Citations (Scopus)

Abstract

The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	9
Pages (from-to)	4469-74
Number of pages	6
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.00126-11
Publication status	Published - Sept 2011

Keywords

Anti-Bacterial Agents
Biofilms
Colistin
Imipenem
Pseudomonas aeruginosa

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10.1128/AAC.00126-11

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abstract = "The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.",

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AU - Hengzhuang, Wang

AU - Wu, Hong

AU - Ciofu, Oana

AU - Song, Zhijun

AU - Høiby, Niels

AU - Wang, Hengzhuang

PY - 2011/9

Y1 - 2011/9

N2 - The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

AB - The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

KW - Anti-Bacterial Agents

KW - Biofilms

KW - Colistin

KW - Imipenem

KW - Pseudomonas aeruginosa

U2 - 10.1128/AAC.00126-11

DO - 10.1128/AAC.00126-11

M3 - Journal article

C2 - 21670181

SN - 0066-4804

VL - 55

SP - 4469

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Abstract

Keywords

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