Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Wang Hengzhuang; Hong Wu; Oana Ciofu; Zhijun Song; Niels Høiby; Hengzhuang Wang

doi:10.1128/AAC.00126-11

Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Wang Hengzhuang, Hong Wu, Oana Ciofu, Zhijun Song, Niels Høiby, Hengzhuang Wang

114 Citationer (Scopus)

Abstract

The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

Originalsprog	Engelsk
Tidsskrift	Antimicrobial Agents and Chemotherapy
Vol/bind	55
Udgave nummer	9
Sider (fra-til)	4469-74
Antal sider	6
ISSN	0066-4804
DOI	https://doi.org/10.1128/AAC.00126-11
Status	Udgivet - sep. 2011

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10.1128/AAC.00126-11

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title = "Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms",

abstract = "The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.",

keywords = "Anti-Bacterial Agents, Biofilms, Colistin, Imipenem, Pseudomonas aeruginosa",

author = "Wang Hengzhuang and Hong Wu and Oana Ciofu and Zhijun Song and Niels H{\o}iby and Hengzhuang Wang",

year = "2011",

month = sep,

doi = "10.1128/AAC.00126-11",

language = "English",

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TY - JOUR

T1 - Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

AU - Hengzhuang, Wang

AU - Wu, Hong

AU - Ciofu, Oana

AU - Song, Zhijun

AU - Høiby, Niels

AU - Wang, Hengzhuang

PY - 2011/9

Y1 - 2011/9

N2 - The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

AB - The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

KW - Anti-Bacterial Agents

KW - Biofilms

KW - Colistin

KW - Imipenem

KW - Pseudomonas aeruginosa

U2 - 10.1128/AAC.00126-11

DO - 10.1128/AAC.00126-11

M3 - Journal article

C2 - 21670181

SN - 0066-4804

VL - 55

SP - 4469

EP - 4474

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Abstract

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