Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

Stine Maarbjerg; Frauke Wolfram; Tone Bruvik Heinskou; Per Rochat; Aydin Gozalov; Jannick Brennum; Jes Olesen; Lars Bendtsen

doi:10.1177/0333102416675618

Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

Stine Maarbjerg^*, Frauke Wolfram, Tone Bruvik Heinskou, Per Rochat, Aydin Gozalov, Jannick Brennum, Jes Olesen, Lars Bendtsen

^*Corresponding author for this work

Department of Clinical Medicine

10 Citations (Scopus)

Abstract

Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.

Original language	English
Journal	Cephalalgia
Volume	37
Issue number	13
Pages (from-to)	1231-1240
Number of pages	10
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102416675618
Publication status	Published - 2017

Keywords

atypical facial pain
clinical characteristics
neuroimaging
orofacial pain
Persistent idiopathic facial pain

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title = "Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI",

abstract = "Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.",

keywords = "atypical facial pain, clinical characteristics, neuroimaging, orofacial pain, Persistent idiopathic facial pain",

author = "Stine Maarbjerg and Frauke Wolfram and Heinskou, {Tone Bruvik} and Per Rochat and Aydin Gozalov and Jannick Brennum and Jes Olesen and Lars Bendtsen",

year = "2017",

doi = "10.1177/0333102416675618",

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pages = "1231--1240",

journal = "Cephalalgia",

issn = "0333-1024",

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number = "13",

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TY - JOUR

T1 - Persistent idiopathic facial pain

T2 - a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

AU - Maarbjerg, Stine

AU - Wolfram, Frauke

AU - Heinskou, Tone Bruvik

AU - Rochat, Per

AU - Gozalov, Aydin

AU - Brennum, Jannick

AU - Olesen, Jes

AU - Bendtsen, Lars

PY - 2017

Y1 - 2017

N2 - Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.

AB - Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.

KW - atypical facial pain

KW - clinical characteristics

KW - neuroimaging

KW - orofacial pain

KW - Persistent idiopathic facial pain

U2 - 10.1177/0333102416675618

DO - 10.1177/0333102416675618

M3 - Journal article

C2 - 27789649

AN - SCOPUS:85033432901

SN - 0333-1024

VL - 37

SP - 1231

EP - 1240

JO - Cephalalgia

JF - Cephalalgia

IS - 13

ER -

Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

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Keywords

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