Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

Stine Maarbjerg; Frauke Wolfram; Tone Bruvik Heinskou; Per Rochat; Aydin Gozalov; Jannick Brennum; Jes Olesen; Lars Bendtsen

doi:10.1177/0333102416675618

Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

Stine Maarbjerg^*, Frauke Wolfram, Tone Bruvik Heinskou, Per Rochat, Aydin Gozalov, Jannick Brennum, Jes Olesen, Lars Bendtsen

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

10 Citationer (Scopus)

Abstract

Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	37
Udgave nummer	13
Sider (fra-til)	1231-1240
Antal sider	10
ISSN	0333-1024
DOI	https://doi.org/10.1177/0333102416675618
Status	Udgivet - 2017

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10.1177/0333102416675618

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title = "Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI",

abstract = "Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.",

keywords = "atypical facial pain, clinical characteristics, neuroimaging, orofacial pain, Persistent idiopathic facial pain",

author = "Stine Maarbjerg and Frauke Wolfram and Heinskou, {Tone Bruvik} and Per Rochat and Aydin Gozalov and Jannick Brennum and Jes Olesen and Lars Bendtsen",

year = "2017",

doi = "10.1177/0333102416675618",

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pages = "1231--1240",

journal = "Cephalalgia",

issn = "0333-1024",

publisher = "SAGE Publications",

number = "13",

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TY - JOUR

T1 - Persistent idiopathic facial pain

T2 - a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

AU - Maarbjerg, Stine

AU - Wolfram, Frauke

AU - Heinskou, Tone Bruvik

AU - Rochat, Per

AU - Gozalov, Aydin

AU - Brennum, Jannick

AU - Olesen, Jes

AU - Bendtsen, Lars

PY - 2017

Y1 - 2017

N2 - Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.

AB - Introduction: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. Methods: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. Results: In a cohort of 53 PIFP patients, the average age of onset was 44.1 years. PIFP was found in more women 40 (75%) than men 13 (25%), p < 0.001. There was a high prevalence of bilateral pain 7 (13%), hypoesthesia 23 (48%), depression 16 (30%) and other chronic pain conditions 17 (32%) and a low prevalence of stabbing pain 21 (40%), touch-evoked pain 14 (26%) and remission periods 10 (19%). The odds ratio between neurovascular contact and the painful side was 1.4 (95% Cl 0.4–4.4, p = 0.565) and the odds ratio between neurovascular contact with displacement of the trigeminal nerve and the painful side was 0.2 (95% Cl 0.0–2.1, p = 0.195). Conclusion: PIFP is separated from trigeminal neuralgia both with respect to the clinical characteristics and neuroimaging findings, as NVC was not associated to PIFP.

KW - atypical facial pain

KW - clinical characteristics

KW - neuroimaging

KW - orofacial pain

KW - Persistent idiopathic facial pain

U2 - 10.1177/0333102416675618

DO - 10.1177/0333102416675618

M3 - Journal article

C2 - 27789649

AN - SCOPUS:85033432901

SN - 0333-1024

VL - 37

SP - 1231

EP - 1240

JO - Cephalalgia

JF - Cephalalgia

IS - 13

ER -

Persistent idiopathic facial pain: a prospective systematic study of clinical characteristics and neuroanatomical findings at 3.0 Tesla MRI

Abstract

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