Periodontitis in patients with cirrhosis: a cross-sectional study

TY - JOUR

T1 - Periodontitis in patients with cirrhosis

T2 - a cross-sectional study

AU - Grønkjær, Lea Ladegaard

AU - Holmstrup, Palle

AU - Schou, Søren

AU - Kongstad, Johanne

AU - Jepsen, Peter

AU - Vilstrup, Hendrik

PY - 2018/2/13

Y1 - 2018/2/13

N2 - BACKGROUND: Many patients with cirrhosis have poor oral health but little is known on periodontitis, and its clinical significance is largely unknown. This study aimed to examine the prevalence and predictors of periodontitis, and evaluate the association of periodontitis with nutritional and systemic inflammation status.METHODS: 145 patients with cirrhosis were consecutively enrolled. Clinical, oral examination of plaque, pocket depth, clinical attachment level, and bleeding on probing was performed. Patients were categorized as having no-or-mild, moderate, or severe periodontitis. Predictors of severe periodontitis and the association with nutritional and systemic inflammation status were analyzed using univariable and multivariable logistic regression analyses.RESULTS: The large majority of patients had periodontitis, 46% of them severely and 39% moderately. Predictors of severe periodontitis included smoking (odds ratio (OR) 2.93, 95% confidence interval (CI) 1.29-6.63), brushing teeth twice daily (OR 0.30, 95% CI 0.11-0.79), and visiting the dentist annually (OR 3.51, 95% CI 1.22-10.81). Cirrhosis etiology or severity was not predictors of severe periodontitis. The patients with severe periodontitis had a higher nutritional risk score than patients with moderate, mild, or no periodontitis (3, interquartile range (IQR) 3-5 vs. 3, IQR 2-4, P = 0.02).CONCLUSIONS: Most cirrhosis patients had significant periodontitis, the severity of which was related to life style factors and was associated with higher nutrition risk score. Our results emphasize the need for further research to establish the effect of periodontitis on cirrhosis.

AB - BACKGROUND: Many patients with cirrhosis have poor oral health but little is known on periodontitis, and its clinical significance is largely unknown. This study aimed to examine the prevalence and predictors of periodontitis, and evaluate the association of periodontitis with nutritional and systemic inflammation status.METHODS: 145 patients with cirrhosis were consecutively enrolled. Clinical, oral examination of plaque, pocket depth, clinical attachment level, and bleeding on probing was performed. Patients were categorized as having no-or-mild, moderate, or severe periodontitis. Predictors of severe periodontitis and the association with nutritional and systemic inflammation status were analyzed using univariable and multivariable logistic regression analyses.RESULTS: The large majority of patients had periodontitis, 46% of them severely and 39% moderately. Predictors of severe periodontitis included smoking (odds ratio (OR) 2.93, 95% confidence interval (CI) 1.29-6.63), brushing teeth twice daily (OR 0.30, 95% CI 0.11-0.79), and visiting the dentist annually (OR 3.51, 95% CI 1.22-10.81). Cirrhosis etiology or severity was not predictors of severe periodontitis. The patients with severe periodontitis had a higher nutritional risk score than patients with moderate, mild, or no periodontitis (3, interquartile range (IQR) 3-5 vs. 3, IQR 2-4, P = 0.02).CONCLUSIONS: Most cirrhosis patients had significant periodontitis, the severity of which was related to life style factors and was associated with higher nutrition risk score. Our results emphasize the need for further research to establish the effect of periodontitis on cirrhosis.

KW - Adult

KW - Aged

KW - Cross-Sectional Studies

KW - Dental Care/utilization

KW - Dental Plaque/epidemiology

KW - Female

KW - Humans

KW - Liver Cirrhosis/complications

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Nutritional Status

KW - Periodontal Attachment Loss/epidemiology

KW - Periodontal Index

KW - Periodontitis/epidemiology

KW - Prevalence

KW - Smoking/adverse effects

KW - Toothbrushing/statistics & numerical data

U2 - 10.1186/s12903-018-0487-5

DO - 10.1186/s12903-018-0487-5

M3 - Journal article

C2 - 29439734

SN - 1472-6831

VL - 18

SP - 1

EP - 7

JO - BMC Oral Health

JF - BMC Oral Health

IS - 1

M1 - 22

ER -