Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity

TY - JOUR

T1 - Perforin and IFN-gamma do not significantly regulate the virus-specific CD8+ T cell response in the absence of antiviral effector activity

AU - Christensen, Jeanette Erbo

AU - Wodarz, Dominik

AU - Christensen, Jan P

AU - Thomsen, Allan R

N1 - Keywords: Animals; CD8-Positive T-Lymphocytes; Interferon-gamma; Membrane Glycoproteins; Mice; Perforin; Pore Forming Cytotoxic Proteins; Rhabdoviridae Infections

PY - 2004

Y1 - 2004

N2 - Using gene-targeted mice we have investigated whether perforin and/or interferon-gamma exert a direct regulatory effect on the expansion and contraction of antigen-specific CD8(+) T cells following infection with a virus (vesicular stomatitis virus) which is not controlled through these molecular effector systems. Unlike what has been observed when these molecules are essential for pathogen clearance, neither molecule was found to play an important role in regulating the kinetics of the virus-specific CD8(+) T cell response in the absence of antiviral effector activity.

AB - Using gene-targeted mice we have investigated whether perforin and/or interferon-gamma exert a direct regulatory effect on the expansion and contraction of antigen-specific CD8(+) T cells following infection with a virus (vesicular stomatitis virus) which is not controlled through these molecular effector systems. Unlike what has been observed when these molecules are essential for pathogen clearance, neither molecule was found to play an important role in regulating the kinetics of the virus-specific CD8(+) T cell response in the absence of antiviral effector activity.

U2 - 10.1002/eji.200424858

DO - 10.1002/eji.200424858

M3 - Journal article

C2 - 15114672

SN - 0014-2980

VL - 34

SP - 1389

EP - 1394

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 5

ER -