Peptide nucleic acids and their potential applications in biotechnology

TY - JOUR

T1 - Peptide nucleic acids and their potential applications in biotechnology

AU - Buchardt, O

AU - Nielsen, Peter E.

PY - 1993/9

Y1 - 1993/9

N2 - Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.

AB - Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.

KW - Biotechnology

KW - DNA/chemistry

KW - DNA, Antisense/chemical synthesis

KW - Drug Design

KW - Molecular Conformation

KW - Molecular Structure

KW - Nucleic Acid Conformation

KW - Nucleic Acids/chemical synthesis

KW - Peptides/chemical synthesis

KW - RNA/chemistry

KW - RNA, Antisense/chemical synthesis

KW - Structure-Activity Relationship

U2 - 10.1016/0167-7799(93)90097-S

DO - 10.1016/0167-7799(93)90097-S

M3 - Journal article

C2 - 7691090

SN - 0167-7799

VL - 11

SP - 384

EP - 386

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 9

ER -