PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients

TY - JOUR

T1 - PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients

AU - Jacobsen, Peter

AU - Grarup, Niels

AU - Tarnow, Lise

AU - Parving, Hans-Henrik

AU - Pedersen, Oluf

PY - 2002

Y1 - 2002

N2 - Recently, an amino acid variant (K121Q) in the glycoprotein PC-1 (Q allele) has been associated with faster progression of diabetic nephropathy, as estimated by calculated creatinine clearance. We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique.

AB - Recently, an amino acid variant (K121Q) in the glycoprotein PC-1 (Q allele) has been associated with faster progression of diabetic nephropathy, as estimated by calculated creatinine clearance. We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique.

KW - Adult

KW - Age of Onset

KW - Amino Acid Substitution

KW - Diabetes Mellitus, Type 1

KW - Diabetic Nephropathies

KW - Disease Progression

KW - Female

KW - Follow-Up Studies

KW - Genetic Variation

KW - Genotype

KW - Glomerular Filtration Rate

KW - Heterozygote Detection

KW - Humans

KW - Male

KW - Phosphoric Diester Hydrolases

KW - Pyrophosphatases

KW - Time Factors

M3 - Journal article

C2 - 12147787

SN - 0931-0509

VL - 17

SP - 1408

EP - 1412

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - 8

ER -