Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan

A Nasr; N C Iriemenam; M Troye-Blomberg; D Arnot; T G Theander; K Berzins; H A Giha; G Elghazali

doi:10.1111/j.1365-3083.2011.02585.x

Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan

A Nasr, N C Iriemenam, M Troye-Blomberg, D Arnot, T G Theander, K Berzins, H A Giha, G Elghazali

Centre for Medical Parasitology

1 Citation (Scopus)

Abstract

The anti-malarial IgG immune response during the lengthy and dry season in areas of low malaria transmission as in Eastern Sudan is largely unknown. In this study, ELISA was used for the measurement of pre-existing total IgG and IgG subclasses to a panel of malaria antigens, MSP2-3D7, MSP2-FC27, AMA-1 and Pf332-C231. The results showed that the antibody responses were predominantly age dependent, antigen specific, and their lifespan was at least 5-6 month long. Generally, the IgG3 was most abundant IgG subclass, and the most recognized antigen was Pf332-C231. Furthermore, the correlation between the levels of IgG subclasses was strongest between IgG1 and IgG3, which were more predictive to the total IgG levels. Finally, the response pattern of each of the IgG subclasses to the different test antigens that were spanning the dry season and the correlation between these responses were described in details for the first time.

Original language	English
Journal	Scandinavian Journal of Immunology
Volume	74
Issue number	4
Pages (from-to)	390-6
Number of pages	7
ISSN	0300-9475
DOIs	https://doi.org/10.1111/j.1365-3083.2011.02585.x
Publication status	Published - 1 Oct 2011

Keywords

Adolescent
Adult
Aged
Antibodies, Protozoan
Antigens, Protozoan
Child
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G
Malaria
Male
Membrane Proteins
Middle Aged
Plasmodium falciparum
Polymerase Chain Reaction
Protozoan Proteins
Seasons
Sudan

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3083.2011.02585.x

Cite this

Nasr, A., Iriemenam, N. C., Troye-Blomberg, M., Arnot, D., Theander, T. G., Berzins, K., Giha, H. A., & Elghazali, G. (2011). Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan. Scandinavian Journal of Immunology, 74(4), 390-6. https://doi.org/10.1111/j.1365-3083.2011.02585.x

Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan. / Nasr, A; Iriemenam, N C; Troye-Blomberg, M et al.
In: Scandinavian Journal of Immunology, Vol. 74, No. 4, 01.10.2011, p. 390-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Nasr, A, Iriemenam, NC, Troye-Blomberg, M, Arnot, D, Theander, TG, Berzins, K, Giha, HA & Elghazali, G 2011, 'Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan', Scandinavian Journal of Immunology, vol. 74, no. 4, pp. 390-6. https://doi.org/10.1111/j.1365-3083.2011.02585.x

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abstract = "The anti-malarial IgG immune response during the lengthy and dry season in areas of low malaria transmission as in Eastern Sudan is largely unknown. In this study, ELISA was used for the measurement of pre-existing total IgG and IgG subclasses to a panel of malaria antigens, MSP2-3D7, MSP2-FC27, AMA-1 and Pf332-C231. The results showed that the antibody responses were predominantly age dependent, antigen specific, and their lifespan was at least 5-6 month long. Generally, the IgG3 was most abundant IgG subclass, and the most recognized antigen was Pf332-C231. Furthermore, the correlation between the levels of IgG subclasses was strongest between IgG1 and IgG3, which were more predictive to the total IgG levels. Finally, the response pattern of each of the IgG subclasses to the different test antigens that were spanning the dry season and the correlation between these responses were described in details for the first time.",

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AB - The anti-malarial IgG immune response during the lengthy and dry season in areas of low malaria transmission as in Eastern Sudan is largely unknown. In this study, ELISA was used for the measurement of pre-existing total IgG and IgG subclasses to a panel of malaria antigens, MSP2-3D7, MSP2-FC27, AMA-1 and Pf332-C231. The results showed that the antibody responses were predominantly age dependent, antigen specific, and their lifespan was at least 5-6 month long. Generally, the IgG3 was most abundant IgG subclass, and the most recognized antigen was Pf332-C231. Furthermore, the correlation between the levels of IgG subclasses was strongest between IgG1 and IgG3, which were more predictive to the total IgG levels. Finally, the response pattern of each of the IgG subclasses to the different test antigens that were spanning the dry season and the correlation between these responses were described in details for the first time.

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KW - Antigens, Protozoan

KW - Child

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KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Malaria

KW - Male

KW - Membrane Proteins

KW - Middle Aged

KW - Plasmodium falciparum

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KW - Protozoan Proteins

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ER -

Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan

Abstract

Keywords

UN SDGs

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