Pattern formation in Pseudomonas aeruginosa biofilms.

TY - JOUR

T1 - Pattern formation in Pseudomonas aeruginosa biofilms.

AU - Parsek, Matthew R

AU - Tolker-Nielsen, Tim

N1 - Paper id:: DOI 10.1016/j.mib.2008.09.015

PY - 2008

Y1 - 2008

N2 - Bacteria are capable of forming elaborate multicellular communities called biofilms. Pattern formation in biofilms depends on cell proliferation and cellular migration in response to the available nutrients and other external cues, as well as on self-generated intercellular signal molecules and the production of an extracellular matrix that serves as a structural 'scaffolding' for the biofilm cells. Pattern formation in biofilms allows cells to position themselves favorably within nutrient gradients and enables buildup and maintenance of physiologically distinct subpopulations, which facilitates survival of one or more subpopulations upon environmental insult, and therefore plays an important role in the innate tolerance displayed by biofilms toward adverse conditions.

AB - Bacteria are capable of forming elaborate multicellular communities called biofilms. Pattern formation in biofilms depends on cell proliferation and cellular migration in response to the available nutrients and other external cues, as well as on self-generated intercellular signal molecules and the production of an extracellular matrix that serves as a structural 'scaffolding' for the biofilm cells. Pattern formation in biofilms allows cells to position themselves favorably within nutrient gradients and enables buildup and maintenance of physiologically distinct subpopulations, which facilitates survival of one or more subpopulations upon environmental insult, and therefore plays an important role in the innate tolerance displayed by biofilms toward adverse conditions.

U2 - 10.1016/j.mib.2008.09.015

DO - 10.1016/j.mib.2008.09.015

M3 - Journal article

C2 - 18935979

SN - 1369-5274

VL - 11

SP - 560

EP - 566

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -