Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

N. Gutman; Mie Johanne Hansen; M. F. Bertelsen; A. M. Bojesen

doi:10.1111/lam.12545

Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

N. Gutman, Mie Johanne Hansen, M. F. Bertelsen, A. M. Bojesen

3 Citations (Scopus)

Abstract

Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils’ biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.

Original language	English
Journal	Letters in Applied Microbiology
Volume	62
Issue number	3
Pages (from-to)	237-242
ISSN	0266-8254
DOIs	https://doi.org/10.1111/lam.12545
Publication status	Published - 1 Mar 2016

Keywords

antimicrobial susceptibility
MIC
minimum inhibitory concentration
Pasteurellaceae
Sarcophilus harrisii
Tasmanian devil

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Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin. / Gutman, N.; Hansen, Mie Johanne; Bertelsen, M. F. et al.

In: Letters in Applied Microbiology, Vol. 62, No. 3, 01.03.2016, p. 237-242.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin",

abstract = "Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils{\textquoteright} biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.",

keywords = "antimicrobial susceptibility, MIC, minimum inhibitory concentration, Pasteurellaceae, Sarcophilus harrisii, Tasmanian devil",

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AU - Bertelsen, M. F.

AU - Bojesen, A. M.

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Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

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Keywords

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