Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

N. Gutman; Mie Johanne Hansen; M. F. Bertelsen; A. M. Bojesen

doi:10.1111/lam.12545

Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

N. Gutman, Mie Johanne Hansen, M. F. Bertelsen, A. M. Bojesen

3 Citationer (Scopus)

Abstract

Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils’ biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.

Originalsprog	Engelsk
Tidsskrift	Letters in Applied Microbiology
Vol/bind	62
Udgave nummer	3
Sider (fra-til)	237-242
ISSN	0266-8254
DOI	https://doi.org/10.1111/lam.12545
Status	Udgivet - 1 mar. 2016

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10.1111/lam.12545

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Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin. / Gutman, N.; Hansen, Mie Johanne; Bertelsen, M. F. et al.

I: Letters in Applied Microbiology, Bind 62, Nr. 3, 01.03.2016, s. 237-242.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin",

abstract = "Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils{\textquoteright} biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.",

keywords = "antimicrobial susceptibility, MIC, minimum inhibitory concentration, Pasteurellaceae, Sarcophilus harrisii, Tasmanian devil",

author = "N. Gutman and Hansen, {Mie Johanne} and Bertelsen, {M. F.} and Bojesen, {A. M.}",

year = "2016",

month = mar,

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doi = "10.1111/lam.12545",

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T1 - Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

AU - Gutman, N.

AU - Hansen, Mie Johanne

AU - Bertelsen, M. F.

AU - Bojesen, A. M.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils’ biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.

AB - Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils’ biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.

KW - antimicrobial susceptibility

KW - MIC

KW - minimum inhibitory concentration

KW - Pasteurellaceae

KW - Sarcophilus harrisii

KW - Tasmanian devil

U2 - 10.1111/lam.12545

DO - 10.1111/lam.12545

M3 - Journal article

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JO - Proceedings of the Society for Applied Bacteriology

JF - Proceedings of the Society for Applied Bacteriology

IS - 3

ER -

Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin

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