Particulate matter air pollution components and risk for lung cancer

O Raaschou-Nielsen; R Beelen; M. Wang; G Hoek; Z J Andersen; B Hoffmann; M Stafoggia; E Samoli; G Weinmayr; K Dimakopoulou; M Nieuwenhuijsen; W W Xun; P Fischer; K T Eriksen; M Sørensen; A Tjønneland; F Ricceri; K de Hoogh; T Key; M Eeftens; P H Peeters; H B Bueno-de-Mesquita; K Meliefste; B Oftedal; P E Schwarze; P Nafstad; C Galassi; E Migliore; A Ranzi; G Cesaroni; C Badaloni; F Forastiere; J Penell; U De Faire; M Korek; N Pedersen; C-G Östenson; G Pershagen; L Fratiglioni; H Concin; G Nagel; A Jaensch; A Ineichen; A Naccarati; M Katsoulis; A Trichpoulou; M Keuken; A Jedynska; I M Kooter; J Kukkonen; B Brunekreef; R S Sokhi; K Katsouyanni; P Vineis

doi:10.1016/j.envint.2015.11.007

Particulate matter air pollution components and risk for lung cancer

O Raaschou-Nielsen, R Beelen, M. Wang, G Hoek, Z J Andersen, B Hoffmann, M Stafoggia, E Samoli, G Weinmayr, K Dimakopoulou, M Nieuwenhuijsen, W W Xun, P Fischer, K T Eriksen, M Sørensen, A Tjønneland, F Ricceri, K de Hoogh, T Key, M EeftensP H Peeters, H B Bueno-de-Mesquita, K Meliefste, B Oftedal, P E Schwarze, P Nafstad, C Galassi, E Migliore, A Ranzi, G Cesaroni, C Badaloni, F Forastiere, J Penell, U De Faire, M Korek, N Pedersen, C-G Östenson, G Pershagen, L Fratiglioni, H Concin, G Nagel, A Jaensch, A Ineichen, A Naccarati, M Katsoulis, A Trichpoulou, M Keuken, A Jedynska, I M Kooter, J Kukkonen, B Brunekreef, R S Sokhi, K Katsouyanni, P Vineis

Center of Epidemiology and Screening

148 Citations (Scopus)

Abstract

BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.

METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.

RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.

CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

Original language	English
Journal	Environment International
Volume	87
Pages (from-to)	66-73
Number of pages	8
ISSN	0160-4120
DOIs	https://doi.org/10.1016/j.envint.2015.11.007
Publication status	Published - 1 Feb 2016

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Raaschou-Nielsen, O., Beelen, R., Wang, M., Hoek, G., Andersen, Z. J., Hoffmann, B., Stafoggia, M., Samoli, E., Weinmayr, G., Dimakopoulou, K., Nieuwenhuijsen, M., Xun, W. W., Fischer, P., Eriksen, K. T., Sørensen, M., Tjønneland, A., Ricceri, F., de Hoogh, K., Key, T., ... Vineis, P. (2016). Particulate matter air pollution components and risk for lung cancer. Environment International, 87, 66-73. https://doi.org/10.1016/j.envint.2015.11.007

Raaschou-Nielsen, O, Beelen, R, Wang, M, Hoek, G, Andersen, ZJ, Hoffmann, B, Stafoggia, M, Samoli, E, Weinmayr, G, Dimakopoulou, K, Nieuwenhuijsen, M, Xun, WW, Fischer, P, Eriksen, KT, Sørensen, M, Tjønneland, A, Ricceri, F, de Hoogh, K, Key, T, Eeftens, M, Peeters, PH, Bueno-de-Mesquita, HB, Meliefste, K, Oftedal, B, Schwarze, PE, Nafstad, P, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Penell, J, De Faire, U, Korek, M, Pedersen, N, Östenson, C-G, Pershagen, G, Fratiglioni, L, Concin, H, Nagel, G, Jaensch, A, Ineichen, A, Naccarati, A, Katsoulis, M, Trichpoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Brunekreef, B, Sokhi, RS, Katsouyanni, K & Vineis, P 2016, 'Particulate matter air pollution components and risk for lung cancer', Environment International, vol. 87, pp. 66-73. https://doi.org/10.1016/j.envint.2015.11.007

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title = "Particulate matter air pollution components and risk for lung cancer",

abstract = "BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.",

author = "O Raaschou-Nielsen and R Beelen and M. Wang and G Hoek and Andersen, {Z J} and B Hoffmann and M Stafoggia and E Samoli and G Weinmayr and K Dimakopoulou and M Nieuwenhuijsen and Xun, {W W} and P Fischer and Eriksen, {K T} and M S{\o}rensen and A Tj{\o}nneland and F Ricceri and {de Hoogh}, K and T Key and M Eeftens and Peeters, {P H} and Bueno-de-Mesquita, {H B} and K Meliefste and B Oftedal and Schwarze, {P E} and P Nafstad and C Galassi and E Migliore and A Ranzi and G Cesaroni and C Badaloni and F Forastiere and J Penell and {De Faire}, U and M Korek and N Pedersen and C-G {\"O}stenson and G Pershagen and L Fratiglioni and H Concin and G Nagel and A Jaensch and A Ineichen and A Naccarati and M Katsoulis and A Trichpoulou and M Keuken and A Jedynska and Kooter, {I M} and J Kukkonen and B Brunekreef and Sokhi, {R S} and K Katsouyanni and P Vineis",

year = "2016",

month = feb,

day = "1",

doi = "10.1016/j.envint.2015.11.007",

language = "English",

volume = "87",

pages = "66--73",

journal = "Environment International",

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TY - JOUR

T1 - Particulate matter air pollution components and risk for lung cancer

AU - Raaschou-Nielsen, O

AU - Beelen, R

AU - Wang, M.

AU - Hoek, G

AU - Andersen, Z J

AU - Hoffmann, B

AU - Stafoggia, M

AU - Samoli, E

AU - Weinmayr, G

AU - Dimakopoulou, K

AU - Nieuwenhuijsen, M

AU - Xun, W W

AU - Fischer, P

AU - Eriksen, K T

AU - Sørensen, M

AU - Tjønneland, A

AU - Ricceri, F

AU - de Hoogh, K

AU - Key, T

AU - Eeftens, M

AU - Peeters, P H

AU - Bueno-de-Mesquita, H B

AU - Meliefste, K

AU - Oftedal, B

AU - Schwarze, P E

AU - Nafstad, P

AU - Galassi, C

AU - Migliore, E

AU - Ranzi, A

AU - Cesaroni, G

AU - Badaloni, C

AU - Forastiere, F

AU - Penell, J

AU - De Faire, U

AU - Korek, M

AU - Pedersen, N

AU - Östenson, C-G

AU - Pershagen, G

AU - Fratiglioni, L

AU - Concin, H

AU - Nagel, G

AU - Jaensch, A

AU - Ineichen, A

AU - Naccarati, A

AU - Katsoulis, M

AU - Trichpoulou, A

AU - Keuken, M

AU - Jedynska, A

AU - Kooter, I M

AU - Kukkonen, J

AU - Brunekreef, B

AU - Sokhi, R S

AU - Katsouyanni, K

AU - Vineis, P

PY - 2016/2/1

Y1 - 2016/2/1

N2 - BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

AB - BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

U2 - 10.1016/j.envint.2015.11.007

DO - 10.1016/j.envint.2015.11.007

M3 - Journal article

C2 - 26641521

SN - 0160-4120

VL - 87

SP - 66

EP - 73

JO - Environment International

JF - Environment International

ER -

Particulate matter air pollution components and risk for lung cancer

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